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Structural bases of proteins and peptides functioning

Вибіркова дисципліна для ОП

First

2021/2022

7 Semester

3

PRO3.Use theories and laws of mathematics, physics, chemistry and other sciences to solve problems of modern biology. PRO4. Understand the basic terms, concepts, principles in the field of biological sciences (in the context of the structure and function of proteins) and on the borders of subject areas. PRO5. Use knowledge and demonstrate compliance with the provisions of biological ethics, biological safety and biological protection. PRO8. Demonstrate knowledge of fundamental biological processes, structure and functions of living organisms. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR16. Choose methods, algorithms for planning and conducting field, laboratory, clinical and laboratory research, including mathematical methods and software for research, processing and presentation of results.

Full-time form

1. Successful mastering of courses "Chemistry", "General Cytology". "Bioorganic Chemistry", "Biochemistry". "Molecular Biology", "Biophysics". 2. Knowledge of the theoretical foundations of organic and bioorganic chemistry, physico-chemical foundations of the phenomena of hydrophilicity and hydrophobicity and chemical structures that provide it. 3. Be able to independently apply previously acquired knowledge of molecular biology, biochemistry, biophysics, etc. disciplines, search for new scientific data, work with scientific and methodological literature,

The discipline "Structural basis of the functioning of proteins and peptides" covers the study of different levels of structural organization of proteins, structure and function of the most important types of proteins - enzymatic, transport, fibrillar, membrane. Considerable attention is paid to the consideration of different levels of structural organization of protein molecules (for example, globins), the domain principle of their construction and the fundamental importance and functions of proteins. In particular, the study of biochemical and molecular mechanisms of catalysis, modern theories of enzyme-substrate interaction is covered. Peculiarities of enzymes functioning and their classification are studied, modern data on their structure and practical application are generalized.

1. D. L. Nelson, M.M. Cox Lehninger Principles of Biochemistry. - New York: W.Y.Freeman and Comp.- 2005- 1119p. 2. Fersht, Alan. Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. Kaissa Publications. Kindle Edition. D.E.Metzler Biochemistry. The chemical reactions of living cells.- Acad. Press.- 2003 - 1950p. 3. Ivet Bahar, Robert L. Jernigan, Ken A. Dill Protein Actions: Principles and Modeling. - Garland Science . - 2017. - 322с.

Lecture, individual work

Semester assessment: I. Modular test 1 - PH 1.1 - 1.5 - 20 points / 10 points 2. Modular test work 2 - PH 1.6 - 1.9-- 20 points / 10 points 3. Modular test work 3 - PH 21-23 - 10 points / 5 points 3. Tests - RN 1.1 - 3.1 - 10 points / 5 points - final assessment: in the form of an exam

Ukrainian