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Synthesis and identification of heterocyclic compounds

ВБ.4.03

Вибіркова дисципліна для ОП

Second

2021/2022

3 Semester

3

P3. Apply the acquired knowledge and understanding to solve new qualitative and quantitative problems of chemistry. P4. Synthesize chemical compounds with specified properties, analyze them and assess compliance with specified requirements. P10. Plan, organize and conduct experimental research in chemistry using modern equipment, competently process their results and draw sound conclusions.

Full-time form

1. Know organic chemistry at the bachelor's degree in Chemistry. 2. Have the skills to write organic reactions. 3. To have an idea of the basics of organic chemistry of heterocyclic compounds at the bachelor's degree in Chemistry. 4. Have the skills of spectral identification of organic matter at the bachelor's degree in Chemistry.

Modern methods of synthesis of heterocyclic compounds (derivatives of three- and four-membered saturated and unsaturated heterocyclic compounds with one and two heteroatoms, as well as saturated and partially unsaturated five- and six-membered five- and six-membered heterocyclic compounds). Structure, chemical properties of heterocyclic compounds and detected biological activity. Relationship between the structure of heterocyclic compounds and biological activity. Physical research methods (1H, 13C, IR, UV and mass spectroscopy) to confirm and establish the structure of heterocyclic compounds. Chemical reactions to obtain heterocyclic derivatives with important functional groups: carbonyl, alcohol, amino, nitro, azo, etc.

1) Joule J.A., Mills K. Heterocyclic chemistry. – Blackwell Science. London. - 2000. - 589 p. 2) Gilchrist T.L. Heterocyclic Chemistry; 3rd ed. – Pearson College Div., 1997. – 414 p. 3) Горічко М.В. Металорганічні похідні гетероциклічних сполук. Навч. посібник для студентів хімічного факультету КНУ. – K.: 2008. − 33 с. 4) Breitmaier E. Structure Elucidation by NMR in Organic Chemistry: A Practical Guide. – Wiley; 3rd ed. – 2002. – 270 p. 5) Smith M.B. Organic synthesis. – McGRAW-HILL, inc. New York, Sydney, Tokyo, Toronto. International editions, 1994. – 1595 p.

Lectures

Evaluation is carried out on a 100-point system. Current control - homework, tests (maximum 60 points), exam (maximum 40 points)

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