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Viruses as vector systems

Вибіркова дисципліна для ОП

Second

2025/2026

2 Semester

4

PR19.8. Apply modern specialized methods for virus research to determine a range of properties used as taxonomic criteria for species identification. PR20.8. Develop a systematic approach to analyzing the emergence and progression of emerging and persistent infections, as well as the mechanisms of viral endogenization, drawing on advanced knowledge acquired through professionally oriented practical courses.

Full-time form

1. Successful mastering of the courses "Virology", "Molecular Biology", "Biotechnology", "Genetics of Viruses" and "Molecular Biology of Viruses". 2. Ability to apply knowledge and skills in the field of virology and molecular genetics, acquired during previous training, to search and analyze the scientific literature. 3. Possession of skills of abstract thinking, analysis and synthesis.

The discipline covers the basic principles of using viruses, or their fragments, to transfer recombinant DNA into the appropriate cell. The discipline considers various approaches to the creation of vectors for cloning nucleic acids and obtaining recombinant proteins based on the genomes of viruses of microorganisms (bacteriophages), invertebrates and vertebrates and humans, including hybrid constructs (cosmids, phagemids, fazmids, bacmids, etc.) and features of their application, scientific and theoretical foundations of practical use of vectors based on human viruses for DNA therapy and DNA vaccination.

1. Вірусологія: підручник / І.Г. Будзанівська, Т.П. Шевченко, Г.В. Коротєєва, О.В. Молчанець, А.В. Харіна, Т.А. Компанець, О.М. Андрійчук, О.В. Шевченко, О.А. Кондратюк. – К.: ВПЦ «Київський університет», 2019. – 351 с. 2. Вірусологія. Навчальний посібник для лабораторних занять / В.П. Поліщук, І.Г. Будзанівська, Т.П. Шевченко, О.М. Андрійчук, Т.А. Компанець, О.А. Кондратюк, Г.В. Коротєєва, О.В. Молчанець, А.В. Харіна, О.В. Шевченко. – К.: ЦП «Компринт», 2017. – 242 с. 3. Компанець Т.А. Віруси як вектори (курс лекцій для студентів біологічного факультету). – К.: Фітосоціоцентр, 2007. 4. Viral vectors for gene therapy: Methods and protocols / Ed. by Machida C.A. – New Jersey: Humana Press, 2003. 5. Viral vectors: basik science and gene therapy / Ed. by Cid-Arregui A., Garcia-Carranca. – Natick: Eaton publishing, 2000.

Lectures, practical classes, independent work

Semester assessment: 1. Module control work 1 - PH 1.1 - 10 points / 5 points 2. Module test 2 - PH 1.2, 2.1, 2.2 - 18 points / 9 points 3. Module test 3 - PH 1.2, 1.3, 2.1, 2.3 - 16 points / 8 points 4. Presentations / reports, oral answers: PH 1.1-1.3 and PH 3.1, 4.1 - 10 points/5 points. 5. Practical work PH 2.1-2.2; 3.1- 6 points/3 points. Final assessment: in the form of an exam

Ukrainian