Infopaket

Molecular organization of chromatin

Вибіркова дисципліна для ОП

First

2022/2023

8 Semester

3

PR06. Apply models, methods and data of physics, chemistry, ecology, mathematics in the process of learning and ensuring professional activity. PR07. To have techniques of self-education and self-improvement. Be able to project the trajectory of professional growth and personal development, applying the acquired knowledge. PR08. Know and understand the basic terms, concepts, theories and laws in the field of biological sciences and at the border of subject areas. PR11. Understand the structural organization of biological systems at the molecular level. PR13. To know the mechanisms of preservation, implementation and transmission of genetic information and their importance in evolutionary processes. PR19. Apply methods of determining structural and functional characteristics of biological systems at different levels of the organization in practical activities.

Full-time form

1. Successful completion of the courses "General cytology", "Biochemistry", "Molecular biology", "General genetics", "Biophysics" 2. Knowledge of the theoretical foundations of biochemistry, molecular biology, genetics and biophysics 3. Ability to independently apply knowledge of molecular biology and other disciplines, use a computer and databases, work with scientific literature.

The course is devoted to the basic principles of structural organization of chromatin (chromosomes) in the interphase nucleus of eukaryotic cells, as well as molecular mechanisms of regulation of functional processes in the nucleus at the level of structural rearrangements of chromatin. The structure and conformational mobility of the nucleosome, supranucleosomal levels of chromatin organization, mechanisms of epigenetic heredity, molecular mechanisms of regulation of DNA transcription and replication and structural changes of chromatin underlying such regulation, as well as principles of modern methods of chromatin structure study are considered.

1. Sivolob AV Molecular biology. - Kyiv: Publishing and Printing Center "Kyiv University ”, 2008, 384 p. 2. Sivolob AV DNA physics. - Kyiv: Publishing and Printing Center "Kyiv University ”, 2011, 335 p. 3. Sivolob AV, Afanasieva KS Molecular organization of chromosomes. - Kyiv: Kyiv University Publishing and Printing Center. 4. Chromatin structure and gene expression: frontiers in molecular biology. S. Elgin, J. L. Workman, eds. - Oxford: Oxford University Press. - 2002. 5. Chromatin structure and dynamics: state-of-the-art. New Comprehensive Biochemistry, Vol. 39. J. Zlatanova, S. H. Leuba, eds. - Amsterdam: Elsevier. - 2004. 6. Nucleic Acid Database, http://ndbserver.rutgers.edu/ 7. Protein Data Bank, www.rcsb.org/pdb/home/home.do 8. EMDataBank, http://www.emdatabank.org/

Lecture, individual work

Semester assessment: 1. Modular test work1: PH 1.1, 1.3, 2.1, 2.2, 2.3 - 20 points / 10 points 2. Modular test work 2: PH 1.2, 1.3, 2.1, 2.2, 2.3 - 20 points / 10 points 3. Presentations, oral presentations, additions: RN 1.1 - 3.1 - 20 points / 10 points - final assessment: in the form of an exam

Ukrainian