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Electrobiophysics and biophysics of ion channels

Вибіркова дисципліна для ОП

First

2022/2023

8 Semester

3

PR06. Apply physics models, methods and data, chemistry, ecology, mathematics in the learning process and ensuring professional activity. PR12. Demonstrate knowledge of structure and processes vital activities and functions of living organisms, to understand the mechanisms of regulation of physiological functions to maintain the homeostasis of biological systems. PR24. Analyze physical and chemical properties and the functional role of biological macromolecules and molecular complexes of living organisms, character their interaction with ions, molecules and radicals, their structure and energetics of processes. PR29.1. Apply the acquired theoretical knowledge and practical skills for planning and conducting scientific experiments in the field of biophysics.

Full-time form

1. Successful mastering of scientific-theoretical and practical material academic disciplines that are taught to students at the educational level "Bachelor", in particular "Biophysics", "Biochemistry", "Physiology and anatomy of man and animals", "Molecular biology", "General genetics". 2. Be able to independently apply knowledge of biophysics, biochemistry, molecular biology, genetics and other disciplines, work with scientific methodological literature. 3. Have skills in working with a computer, materials and equipment used in biological laboratories.

The subject of the discipline is the study of electrical properties of cells and tissues, physicochemical processes that underlie electrogenesis, including biophysical and molecular mechanisms of formation and maintenance of transmembrane ion gradients and transmembrane ion transport. The main electrophysiological methods of multicellular preparations and isolated cells, principles of modern robotic patch-terminal systems, basic principles of classical ion channel biophysics, molecular biophysics and ion channel physiology, modern classification of potential- and ligand-controlled ion channels and their biophysical functions and their biophysical functions are considered. and molecular mechanisms of calcium homeostasis and signaling. In the future, the acquired knowledge and skills in the field of "Electrobiophysics and biophysics of ion channels" can be used in research in the field of biophysics and in interdisciplinary research.

1. Shuba MF, Davydovskaya TL, Prylutsky YI, Zholos OV, Bogutskaya KI Electrobiophysics. - Kyiv: Phytosocial Center, 2002. - 152 p. 2. Davydovska TL, Miroshnichenko MS, Prylutsky YI, Zholos OV (2006). Theoretical and experimental foundations of biophysics of electrical phenomena. K .: Phytosocial center, 190 p. 3. Shuba YM Fundamentals of molecular physiology of ion channels. - К.: Наук. Opinion, 2010. - 447 c. 4. Hille B. Ion channels of excitable membranes, 3rd Edition. - Sunderland, Massachusetts, USA: Sinauer Associates, 2001. - 814 p. 5. Kandel E.R., Schawartz J.H., Jessel T.M., Siegelbaum S.A., Hudspeth A.J. Principals of neural science, 5th Edition. - The McGeaw-Hill Companies, Inc., 2013. - 1760 p.

Lecture, individual work

- current evaluation / control: 1. Modular control work 1 – RN 1.1; 1.2. – 20 points/10 points 2. Modular control work 2 - RN 1.3; 1.4– 20 points/10 points 3. Essay - RN 2.3 - 10 points/5 points 4. Presentation – RN 3.1 – 10 points/5 points - final assessment: in the form of an exam

Ukrainian