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Structural bases of proteins and peptides functioning

Вибіркова дисципліна для ОП

First

2022/2023

7 Semester

3

PR08. Know and understand basic terms, concepts, theories and laws in the field of biological sciences and on the verge of pre- heavy industries. PR11. Understand the structural organization of biological systems at the molecular level. PR16. Know the structure and functions of the immune system, cli- physical and molecular mechanisms of immune reactions, their regulation, genetic control; types of immunity and methods of assessing the body's immune status PR19. Apply methods in practical activities determination of structural and functional characteristics researcher of biological systems at different levels of organization tions

Full-time form

1. Successful completion of the courses "Chemistry", "General Cytology", "Bioorganic Chemistry", "Bi- chemistry", "Molecular biology", "Biophysics". 2. Be able to independently apply previously acquired knowledge of molecular bio- logy, biochemistry, biophysics, etc. disciplines for solving specific scientific practical tasks; work with scientific and scientific methodical literature, search for new scientific data, work with scientific and methodical literature tour 3. Mastery of basic system analysis skills.

The discipline "Structural basis of the functioning of proteins and peptides" covers the study of different levels of structural organization of proteins, structure and function of the most important types of proteins - enzymatic, transport, fibrillar, membrane. Considerable attention is paid to the consideration of different levels of structural organization of protein molecules (for example, globins), the domain principle of their construction and the fundamental importance and functions of proteins. In particular, the study of biochemical and molecular mechanisms of catalysis, modern theories of enzyme-substrate interaction is covered. Peculiarities of enzymes functioning and their classification are studied, modern data on their structure and practical application are generalized.

1. Ivet Bahar, Robert L. Jernigan, Ken A. Dill Protein Actions: Principles and Modeling. - Garland Science . - 2017 . - 322 Pages. 2. D. L. Nelson, M.M. Cox Lehninger Principles of Biochemistry. - New York: W.Y.Freeman and Comp; 8-th edition- 2021- 1248p. 3. Garrett, R., Grisham, C. and Sabat, M. Biochemistry. – Boston, USA: Cengage Learning. – 2017. –863p. 4. H. Stephen Stoker. General, organic, and biological chemistry. – Boston, MA, USA : Cengage Learning. 2016. – 1030p. 5. Остапченко Л.І., Андрійчук. Т.Р., Рибальченко В.К. та ін. Біохімія - Підручник для студентів ВНЗ. — Київ : Київський університет, 2016. — 798. 6. Fersht, Alan. Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. Kaissa Publications. Kindle Edition. D.E.Metzler Biochemistry. The chemical reactions of living cells.- Acad. Press.- 2003 - 1950p.

Lecture, individual work

Semester assessment: I. Modular test 1 - PH 1.1 - 1.5 - 20 points / 10 points 2. Modular test work 2 - PH 1.6 - 1.9-- 20 points / 10 points 3. Modular test work 3 - PH 21-23 - 10 points / 5 points 3. Tests - RN 1.1 - 3.1 - 10 points / 5 points - final assessment: in the form of an exam

Ukrainian