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Molecular mechanisms of cell differentiation

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

5

PR02. Use libraries, information databases, Internet resources to find the necessary information PR04. Solve complex problems in the field of biology, generate and evaluate ideas. PR06. Analyze biological phenomena and processes at the molecular, cellular, organismal, population-species and biosphere levels from the point of view of fundamental general scientific knowledge, as well as using modern methods of research The rest of the results are specified in the Work Program of the discipline

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1. Successful completion of the courses "Biology of individual development", "Cytology", "Genetics", "Molecular biology", "Biochemistry". 2. Knowledge of theoretical foundations, molecular biology (biochemistry, genetics, cytology, embryology, cell biology). 3. Ability to independently apply knowledge from the above disciplines, perform laboratory and practical work, work with scientific literature and electronic databases, predict and critically evaluate research results, ability to system analysis.

The course includes an overview of current knowledge on the mechanisms of cell determination and differentiation at the molecular level. During the course, the student gets acquainted with the basic patterns and molecular mechanisms of cell determination and differentiation, as well as the principles of selective gene expression. Particular attention is paid to the behavior of stem cells, the processes of neurogenesis, the peculiarities of cell differentiation, as well as pathologies associated with violations of the coordination and control of cell differentiation processes.

1. Afanasieva K., Sivolob A. Kinetic approach in comet assay: an opportunity to investigate DNA loops // in A closer look at the Comet Assay. Ed. K.H. Harmon. NY: Nova science publishers, 2019. - pp.65-84.. 2. Afanasieva K., Chopei M., Zazhytska M., Vikhreva M., Sivolob A.. DNA Loop Domain Organization as Revealed by Single-Cell Gel Electrophoresis // Biochim. Biophys Acta-Mol. Cell Res. — 2013. — Vol. 1833, Ks4. — P.3237 — 3244. 3. Berger, S.L. The complex language of ehromatin regulation during transcription // Nature. — 2007 — Vol. 447. — P. 407-412. 4. Boeger, H., Bushnell, D.A., Davis, R et al. Stnictural basis of eukaryotic gene transcription 1/ FEBS Letters. — 2005. — Vol. 579. — P. 899—903. 5. Carter, D.R.F., Eskiw, C., Cook, P.R. Transcription factories // Biochem. Soc. Trans. — 2008. — Vol. 36. — P. 585—589.

Lectures, practical work, independent work.

- semester assessment: 1. Modular control po6omal. RI 1.1-1.3 - 40 points/20 points 2. Modular control work 2: RI 1.1-1.3 — 30 points/15 points 3. Solving research problems. RI 1.1 — 2.2 — 10 points/5 points 4. Evaluation, presentations, oral answers and additions: PH 1.1 — 4.1 20 points/10 points - final evaluation: in the form of credit

Ukrainian