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Biochemical mechanisms of cell damage

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

5

PR04. Solve complex problems in the field of biology, generate and evaluate ideas. PR06. Analyze biological phenomena and processes at the molecular, cellular, organismal, population-species and biosphere levels in terms of basic general scientific knowledge, as well as using special modern research methods. PR07. Describe and analyze the principles of structural and functional organization, mechanisms of regulation and adaptation of organisms to the influence of various factors. PR08. Apply during research knowledge of the peculiarities of the development of modern biological science, the basic methodological principles of scientific research PR16. Critically comprehend theories, principles, methods in various fields of biology to solve practical problems and problems. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods.

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Successful mastering of scientific-theoretical and practical material of academic disciplines taught to students of EL "Bachelor". 2. Be able to independently apply knowledge of molecular biology, biochemistry, microbiology, etc. disciplines, perform laboratory and practical work, work with scientific and methodological literature. 3. Have basic skills in working with materials and equipment used in biological and biotechnological laboratories.

"Biochemical mechanisms of cell damage" - a discipline aimed at studying the mechanisms of response to damaging stimuli of various etiologies at the molecular and biochemical levels. The classification, types and principles of action of pathological stimuli on cells are considered. Particular attention is paid to the various stages of development of programmed cell death, the structure and functions of major regulators and mediators involved in the development of stress response in different cell types.

Berg, J. M., Timoshko, J. L. & Strier, L. Biochemistra. Freeman, 7th edition, 2011. Lodish, H., Burke, A., Zhipursky, S. L., Matsudaira, P., Baltimore, D. and James Darnell, J. Molecular Cell Biology, Freeman, 7th edition 2013. Nelson, DL & Cox, MM Lehninger Principles of Biochemistry. Freeman, 6th edition, 2013. Ryter, S. W., Cloonan, S. M. & Choi, A. M. Autophagy: critical regulator of cellular metabolism and homeostasis. Mol. Cells 36, 7-16 (2013). Choi, A. M., Ryter, S. W. & Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 368, 651-662 (2013). Yuan, J. & Kroemer, G. Alternative cell death mechanisms in development and beyond. Gene Dev. 24, 2592-2602 (2010). Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G. & Linkermann, A. Molecular mechanisms of regulated necrosis. Semin. celldev. Biol. 35, 24-32 (2014).

Lectures, practical classes, independent work.

1. Modular test 1 (remote) - PH 1.1; 1.2. - 20 points / 10 points 2. Modular test work 2 (remote) - PH 1.3; 1.4 - 20 points / 10 points 4. Minutes of practical classes / conclusions - PH 2.1 - 14 points / 7 points 5. Test (testing) PH 4.1 - 6 points / 3 points - final assessment: in the form of an exam

Ukrainian