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Structure and functions of peptides and proteins

Вибіркова дисципліна для ОП

First

2021/2022

6 Semester

3

PRO3. Use theories and laws of mathematics. physics, chemistry and other sciences to solve problems of modern biology PRO4. Understand the basic terms, concepts, principles in the field of biological sciences (in the context of the structure and function of proteins) PRO7. Demonstrate knowledge of the structural organization of biological systems at the molecular level of the organization. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology. PR21. Solve applied problems of biology by appropriate methods. PR23.2 Have basic methods of modern biochemistry

Full-time form

1. Successful mastering of the courses "Bioorganic Chemistry", "General Cytology", "Biochemistry", "Molecular Biology", "Biophysics". 2. Knowledge of the theoretical foundations of organic and bioorganic chemistry, physico-chemical foundations of hydrophilicity and hydrophobicity and chemical structures that provide it. 3. Be able to independently apply previously acquired knowledge in molecular biology, biochemistry, biophysics, etc., disciplines, search for new scientific data, work with scientific and methodological literature.

The course "Structure and functions of peptides and proteins" introduces students to modern principles of structure, classification, physicochemical properties and biological functions of proteins and peptides. Particular attention is paid to the most important characteristics of amino acids, which make them unique structural elements of all living proteins. The concepts of the levels of structural organization of protein molecules, the domain principle of their construction and the fundamentality of the meaning and functions of proteins, which are directly determined by their structure, are also provided. The concept of folding, its dynamics and control mechanisms are considered. The discipline presents modern ideas about the classification of proteins, as well as prospects for the study, production and use of proteins and peptides in pharmaceuticals and various industries.

1. D. L. Nelson, M.M. Cox Lehninger Principles of Biochemistry. - New York: W.Y.Freeman and Comp.- 2005- 1119p. 2. G. C. barrett, D. T. Elmore Amino Acids and Peptides. — Cambridge university press. - 2004. — p.225 3. Губський Ю.І. Біологічна хімія. - К.; Тернопіль: Укрмедкнига, 2000. — 508 4. Fersht, Alan. Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding. Kaissa Publications. Kindle Edition. 5. D.E.Metzler Biochemistry. The chemical reactions of living cells.- Acad. Press.- 2003 - 1950p. 6. Ivet Bahar, Robert L. Jernigan, Ken A. Dill Protein Actions: Principles and Mod- eling. - Garland Science . - 2017 . - 322 Pages.

Lecture, individual work

Semester assessment: 1. Modular test 1 - PH 1.1 - 1.5 - 20 points / 10 points 2. Modular test work 2 - PH 1.6 - 1.9 - 20 points / 10 points 3. Modular control work C - PH 2.1 - 2.3- 3.1 - 10 points / 5 points 4. Tests - RN 1.1 - 1.9, 2.1 - 2.3, - final assessment: in the form of an exam

Ukrainian