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Molecular organization of chromatin

Вибіркова дисципліна для ОП

First

2024/2025

10 Semester

3

PR06. Apply models, methods and data of physics, chemistry, ecology, mathematics in the process of learning and ensuring professional activity. PR07. Possess methods of self-education and self-improvement. Be able to design a trajectory of professional growth and personal development, applying the acquired knowledge. PR08. Know and understand the basic terms, concepts, theories and laws in the field of biological sciences and at the border of subject areas. PR11. Understand the structural organization of biological systems at the molecular level. PR13. Know the mechanisms of preservation, implementation and transmission of genetic information and their significance in evolutionary processes.

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Successful mastering of courses "Cytology", "Biochemistry", "Molecular Biology", "Genetics", "Biophysics" Knowledge of the theoretical foundations of biochemistry, molecular biology, genetics and biophysics Ability to independently apply knowledge of molecular biology and other disciplines, use computers and databases, work with scientific literature.

The course is devoted to the basic principles of structural organization of chromatin (chromosomes) in the interphase nucleus of eukaryotic cells, as well as molecular mechanisms of regulation of functional processes in the nucleus at the level of structural rearrangements of chromatin. The structure and conformational mobility of the nucleosome, supranucleosomal levels of chromatin organization, mechanisms of epigenetic heredity, molecular mechanisms of regulation of DNA transcription and replication and structural changes of chromatin underlying such regulation, as well as principles of modern methods of chromatin structure study are considered.

1. Sivolob A.V. Molecular biology. - K .: Publishing and printing center "Kyiv University", 2008, 384 p. 2. Sivolob A.V. Physics of DNA. - K .: Publishing and printing center "Kyiv University", 2011, 335 p. 3. Sivolob A.V., Afanas'eva K.S. Molecular organization of chromosomes. - K.: Publishing and printing center "Kyiv University". 4. Chromatin structure and gene expression: frontiers in molecular biology. S. Elgin, JL Workman, eds. – Oxford: Oxford University Press. - 2002. 5. Chromatin structure and dynamics: state-of-the-art. New Comprehensive Biochemistry, Vol. Thirty-ninth J. Zlatanova, S. H. Leuba, eds. – Amsterdam: Elsevier. – 2004.

Lectures, independent work

Semester assessment: 1. Modular test work1 (remotely): PH 1.1, 1.3, 2.1, 2.2, 2.3 - 20 points / 10 points 2. Modular test work 2: PH 1.2, 1.3, 2.1, 2.2, 2.3 - 20 points / 10 points 3. Presentations, oral presentations, additions: PH 1.1 - 3.1 - 20 points / 10 points Final assessment: in the form of an exam

Ukrainian