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Eukaryotic chromosomes

Вибіркова дисципліна для ОП

First

2022/2023

9 Semester

3

PR03. Use theories and laws of mathematics, physics, chemistry and other sciences to solve problems of modern biology. PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the boundaries of subject areas. PR07. Demonstrate knowledge of the structural organization of biological systems at the molecular level of the organization. PR09. Demonstrate knowledge of heredity and variability, molecular mechanisms of conservation and realization of genetic information and importance in evolutionary processes. PR13. Analyze the data of biological science to understand the role of the evolutionary idea of ​​the organic world. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology.

External form

Successful mastering of the courses "Genetics", "Molecular Biology", "Biochemistry", "Cytology", as well as acquaintance with selected sections of the biology of individual development, evolution, taxonomy. Knowledge of the theoretical foundations of chemistry, physics, molecular biology, cell biology, etc .; ability to use theoretical knowledge of these disciplines to solve practical problems. Possession of basic skills in working with scientific electronic databases, scientific literature and the ability to system analysis.

The discipline is a basic genetic course, which is devoted to the study of the principles of molecular organization of chromosomes of eukaryotic cells and patterns of control of their behavior in the cell cycle. Mechanisms of chromatin fibril compaction, molecular organization of centromeric, telomeric and subtelomeric regions of chromosomes are considered, principles of cellular control of chromosome segregation during divisions are demonstrated. The variety of types of structural organization of eukaryotic chromosomes is covered, as well as modern principles of molecular evolution of karyotypes are considered. Particular attention is paid to genetic pathologies associated with dysfunction of the chromosomal apparatus of the cell and disorders of cell cycle control.

1. Sivolob A.V., Afanas'eva K.S. Molecular organization of chromosomes. - M.: Publishing and printing center "Kyiv University", 2014. 2. Sivolob A.V. Molecular biology. - K .: Publishing and printing center "Kyiv University", 2008. 3. Chromatin structure and dynamics: state-of-the-art. New Comprehensive Biochemistry, Vol. Thirty-ninth J. Zlatanova, S. H. Leuba, eds. – Amsterdam: Elsevier. – 2004. 4. Chromosome Structure and Aberrations. Bhat T.A, Wani A.A., eds. – India: Springer. – 2017. 5. Lodish H., Berk A., Zipursky S.L., et al Molecular cell biology 4th edition – W.H. Freeman and company, 2001, 1084

Lectures, independent work

Semester assessment: 1. Modular test 1 (remotely): PH 1.1 - 1.3, 2.1, 2.4 - 20 points / 10 points (block of topics of Section 1) 2. Modular test work 2: PH 1.3 - 1.5, 2.2-2.4 - 20 points / 10 points (block of topics of Section 2) 3. Solution of research problems: PH 1.1 - 3.1 - 10 points / 5 points 4. Evaluation of additions, answers: PH 1.1 - 3.1 - 10 points / 5 points Final assessment: in the form of an exam

Ukrainian