Infopaket

Regulation of gene expression

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

4

PP02. Use libraries, information databases, Internet resources to find the necessary information. PR04. Solve complex problems in the field of biology, generate and evaluate ideas. PR06. Analyze biological phenomena and processes at the molecular, cellular, organismal, population-species and biosphere levels in terms of basic general scientific knowledge, as well as using special modern research methods. PP10. Presented the results of scientific work in writing (in the form of a report, scientific publications, etc.) and orally (in the form of reports and defense of the report) using modern technologies. argue their position in the scientific discussion. PP12. Use innovative approaches to solve complex problems of biology under uncertain conditions and requirements. PPl4. Adhere to the norms of academic integrity in the study and conduct of scientific activities, know the basic legal norms for the protection of intellectual property.

Full-time form

1. Successful mastering of the courses "Biochemistry", "Genetics", "Molecular Biology", "Biology of Individual Development". 2. Knowledge of theoretical foundations, molecular biology; biochemistry, genetics, cytology, embryology, cell biology. 3. Ability to independently apply knowledge of the above disciplines, perform laboratory and practical work, work with scientific literature and electronic databases, predict and critically evaluate research results, ability to system analysis.

The course is devoted to the study of molecular mechanisms of gene activation and function in prokaryotic and eukaryotic cells, as well as control systems for these processes. The role of intercellular communications in the regulation of gene expression during cell differentiation is considered, special attention is paid to the role of non-coding RNA and proteins in the regulation of gene function. Examples of diseases and anomalies associated with the violation of cellular control systems for the regulation of genes are given. Methods of analysis of gene expression and modern directions of research of this problem are demonstrated, the range of perspective projects in this field is outlined.

1. Afanasieva KS Regulation of gene expression. Lecture notes, Kyiv, 2021. 2. Sivolob AV Molecular biology. - Kyiv: University of Kyiv. - 2008 3. Sivolob AV, Afanasieva KS Molecular organization of chromosomes. - Kyiv: University of Kyiv. - 2013, 287 p. 4. Alberts W., Johnson A., Lewis Y., Raff M., Roberts K., Walter R. Molecular Biology of the Cell. Fifth Edition - New York, Garland Science, 2007. 5. Bradshaw R.A., Dennis E.A. Handbook of Cell Signaling - Elsevier, 2003. 6. Krauss G. Biochemistry of Signal Transduction and Regulation. 4thEdition. - WILEY-VCH Verlag GmbH & Co., 2008. 7. Moody S.A. Principles of developmental genetics. - Elsevier, 2007.

Lectures, practical work, independent work

1. Modular control works. 3. Solving research problems. 4. Evaluation of additions, presentations, oral and oral answers, abstract. - final assessment: in the form of a credit.

Ukrainian