Infopaket

Molecular organization of chromatin

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

5

PR04. Solve complex problems in the field of biology, generate and evaluate ideas. PR06. Analyze biological phenomena and processes at the molecular, cellular, organismal, population-species and biosphere levels in terms of fundamental general scientific knowledge, as well as the use of special modern research methods. PR 12. Use innovative approaches to solve complex problems of biology under uncertain conditions and requirements. GIR 17. Apply modern learning technologies for teaching special disciplines. PR 1 9. Solve scientific-theoretical, research and applied problems of biology by appropriate methods. PR12. Apply professional knowledge and practical skills to solve research and practical problems in the field of molecular biology and develop practical recommendations based on the results of research in the field of molecular biology and related sciences.

Full-time form

1. Successful mastering of the Bachelor's degree, 2. Ability to independently use computers and databases, work with scientific literature, 3. Possession of basic skills of system analysis.

The course is devoted to the basic principles of structural organization of chromatin (chromosomes) in the interphase nucleus of a eukaryotic cell, as well as molecular mechanisms of regulation of functional processes in the nucleus at the level of chromatin rearrangements. The structure and conformational mobility of the nucleosome, supranucleosomal levels of chromatin organization, mechanisms of epigenetic heredity, molecular mechanisms of regulation of transcription and replication of DNA, and structural changes in the chromatin principle are considered in this method.

1. Sivolob AV Molecular biology. - Kyiv: Publishing and Printing Center "Kyiv University", 2008 "Z84 p. 2. Сиволоб д.В. Physics of DNA - K .: Publishing and Printing Center "Kyiv University",? 01 1, 335 p. Z. Sivolob AV. Afanasieva KS Molecular organization of chromosomes. - Kyiv: Publishing and Printing Center "Kyiv University". 4. Clrromatin structure and gene expression: frontiers in molecular biology. S.Elgin, J.L.Wotknran, eds. - Oxford: ОхтЬrd UrriveTsity Press. -2002. 5. Clrronratin structure arrd dynarnics: state-ot - the-art. New Comprelrensive Biochenristry, Vol. 39. J.Zlatanoya. S.H.Leuba, eds. - AnrsteTdam: Elsevier. - 2004.

Lectures, practical classes, seminars, independent work.

- semester assessment: 1. Modular test 1): pH 1.1 - 2.3 - 20 points / 10 points 2. Modular test, work 2: pH 1.1- 2.3 - 20 points / I0 points 3, Practical works of presentation, reports, reports: РН 1,1 - 4,1 - 20 points / 10 points - final assessment: in the form of an exam

Ukrainian