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Physics of DNA and protein-nucleic interactions

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

5

PR9. Plan research, choose effective research methods and their material support. PR11. To carry out statistical processing, analysis and generalization of the received experimental data with use of software and modern information technologies. PR14. Adhere to the norms of academic integrity in the study and conduct of scientific activities, know the basic legal norms for the protection and intellectual property. PR23. Be able to use modern physical and physico - chemical methods in biological research, as well as methods of working with modern information and communication systems.

External form

1. Successful mastering of the courses "Biochemistry", "Molecular Biology", "Biophysics" 2. Knowledge of the theoretical foundations of mathematics, physical chemistry, molecular physics, biochemistry, molecular biology and biophysics 3. Ability to independently apply knowledge of molecular biology, etc. disciplines, perform laboratory and practical work, work with scientific literature.

The course is devoted to the basic principles of structural organization, physical behavior and functioning of DNA. The structure and conformational mobility of DNA, mechanisms of stabilization of the double helix, regularities of its cooperative structural transformations, electrostatics of DNA, basics of polymer physics, topology of circular DNA, structure and conformational dynamics of protein-nucleic complexes, thermodynamics and kinetics nucleotide sequence of proteins, principles of modern methods of research of nucleic acids and protein-nucleic interactions.

1. Sivolob A.V. Molecular biology. - K .: Publishing and printing center "Kyiv University", 2008, 384 p. 2. Sivolob A.V. Physics of DNA. - K .: Publishing and printing center "Kyiv University", 2011, 335 p. 3. Bloomfield V.A., Crothers D.M., Tinoco I. Nucleic acids: structures, properties and functions. - Sausalito, CA, USA: University Science Books, 2000.

Lectures, independent work, laboratory work.

-semester assessment: 1. Modular control for work1 (remote): PH 1.1 - 10 points / 5 points 2. Modular test 2 (remotely): PH 1.2 - 10 points / 5 points 3. Final modular test: PH 1.1 - 4.1 - 20 points / 10 points 4. Laboratory works (2 works): PH 2.1, 2.2, 3.1– 10 points / 5 points for each - final assessment: in the form of an exam

Ukrainian