Infopaket

Protein-nucleic interactions

Вибіркова дисципліна для ОП

Second

2021/2022

3 Semester

4

PR2. Use libraries, information databases, Internet resources to find the information you need. PR11. To carry out statistical processing, analysis and generalization of the received experimental data with use of software and modern information technologies. PR18. Model objects and processes in living organisms and their components using mathematical methods and information technology. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods. PR20. On the basis of in-depth knowledge of natural sciences to form an idea of ​​the laws of individual and historical development of biological systems at different levels of organization, the role of systemic processes in their formation, functioning and plasticity, features of their cooperative interaction.

Full-time form

Successful mastering of the courses "Biochemistry", "Molecular Biology", "Biophysics" Knowledge of the theoretical foundations of physical chemistry, molecular physics, biochemistry, molecular biology and biophysics Ability to independently apply knowledge of molecular biology, etc. disciplines, perform laboratory and practical work, work with scientific literature.

The course is devoted to the basic principles of protein interactions with nucleic acids. The structure and conformational mobility of protein-nucleic complexes, bases of thermodynamic and kinetic analysis of protein-nucleic interactions, mechanisms of specific recognition of nucleotide sequences by proteins, principles of modern methods of research of protein-nucleic interactions are considered.

Леск, А.М. Introduction to protein architecture: the structural biology of proteins. - Oxford: Oxford University Press, 2001. Sivolob AV Molecular biology. - Kyiv: Publishing and Printing Center "Kyiv University", 2008, 384 p. Sivolob AV DNA physics. - Kyiv: Publishing and Printing Center "Kyiv University", 2011, 335 p. Bloomfield VA, Crothers DM, Tinoco I. Nucleic acids: structures, properties and functions. - Sausalito, CA, USA: University Science Books, 2000.

Lectures, practical classes, independent work

1. Modular test work1: PH 1.1 - 30 points / 15 points 2. Modular test work 2: PH 1.2 - 30 points / 15 points 3. Solving practical problems: PH 1.1 - 4.1 - 30 points / 15 points 4. Evaluation of additions, answers, abstract: RN 1.1 - 4.1 - 10 points / 5 points - final assessment: in the form of a credit

Ukrainian