Infopaket

Medical genetics with basics of pharmacogenetics

Вибіркова дисципліна для ОП

Second

2021/2022

3 Semester

4

PR4. Solve complex problems in the field of biology, generate and evaluate ideas. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods. PR29. Be able to use modern specialized methods of molecular and population genetics and genetic analysis.

Full-time form

Successful mastering of the courses “Molecular Biology? "Immunology? "Virology", "General Genetics", "Biochemistry", "Human Genetics", "Oncogenetics", "Genomics", "Eukaryotic Chromosomes", "Chromatin Molecular Organization" and "Genome Instability". 2. Knowledge of the theoretical foundations of chemistry, physics, molecular biology, cell biology, etc .; ability to use theoretical knowledge of these disciplines to solve practical problems. 3. Possession of basic skills in working with scientific electronic databases, scientific literature and the ability to system analysis.

The course covers the study of inheritance and variability of human pathological traits. The classification of hereditary diseases, molecular mechanisms of pathological conditions in the manifestation of chromosomal and genetic hereditary diseases are considered. Attention is paid to hereditary predisposition to "sporadic" diseases (cancer, mental, cardiovascular diseases, etc.). The connection of different polymorphic variants of the human genome with different pathological conditions is considered. General information on pharmacokinetics and pharmacodynamics of drugs, causes of individual sensitivity to drugs, genetic variants of drug transport and metabolism systems, pharmacological aspects of genetic variants of drug target molecules are considered. Problems of appointment of individual schemes of drug therapy depending on a genotype of the patient are discussed.

Medical genetics // ed. Grechanina O.Ya. - К .: Медицина, 2007. Rushkovsky SR Pharmacogenetics. Course of lectures. - Kyiv: NSC "Institute of Biology", 2013. Grody W., Korf B., Pyeritz R. Emery and Rimoin’s principles and practice of medical genetics and genomics. Clinical principles and applications. - Academic Press, 2019. Handbook of Clinical Adult Genetics and Genomics: A Practice-based Approach // eds. Dhar S., Nagamani S.S.Ch., Eble T. - Academic Press, 2020

Lectures, laboratory work, independent work

Modular test work1: PH 1.1 - 1.4 - 20 points / 10 points (block of topics of Section 1) 2. Modular test work 2: PH 1.1 - 1.4 - 20 points / 10 points (block of topics of Section 2) 3. Evaluation of laboratory work: RN 2.1 - 4.1 - 10 points / 5 points 4. Evaluation of additions, oral answers, presentations: RN 1.1 - 4.1 - 10 points / 5 points - final assessment: in the form of an exam

Ukrainian