Infopaket

Genome instability

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

4

PR7. Describe and analyze the principles of structural and functional organization, mechanisms of regulation and adaptation of organisms to the influence of various factors. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods. PR30. Be able to form a system of analysis and interpretation of new results on the organization and functioning of living systems at the molecular, cellular, organismal and population levels based on in-depth knowledge of the disciplines of vocational training.

Full-time form

PR7. Describe and analyze the principles of structural and functional organization, mechanisms of regulation and adaptation of organisms to the influence of various factors. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods. PR30. Be able to form a system of analysis and interpretation of new results on the organization and functioning of living systems at the molecular, cellular, organismal and population levels based on in-depth knowledge of the disciplines of vocational training.

"Genome instability" considers the phenomenon of genome instability as a fundamental and integral property. Attention is paid to the general causes of genome instability, molecular repair mechanisms that ensure genome stabilization, the role of specific genomic sequences, mobile genetic elements, chromatin structures in the stabilization and destabilization of the genome. Attention is paid to the mechanisms of genome destabilization in normal and pathological processes. The role of genome instability in micro- and macroevolution is discussed.

Afanasyeva KS, Pronina OV, Rushkovsky SR Methodical instructions for the special workshop "Genome instability" for students of the Faculty of Biology // Kyiv: Phytosocial Center, 2006. Sivolob AV, Rushkovsky SR, Kiryachenko SS and others. Genetics: a textbook. - Kyiv: Kyiv University Publishing and Printing Center, 2008. Nasheuer P.H. Genome Stability and Human Diseases - Springer Verlag, 2010. Khanna KK, Shilo Y. The DNA Damage Response - Springer Verlag, 2009. Miller W.J., Capy P. Mobile Genetic Elements - Humana Press, 2004.

Lectures, laboratory work, independent work

1. Modular test work1: PH 1.1 - 2 .5– 35 points / 15 points (block of topics of Section 1) 2. Modular test work 2: PH 1.1 - 2.5– 35 points / 15 points (block of topics of Section 2) 3. Evaluation of laboratory work: RN 2.1 - 4.1 - 20 points / 10 points 4. Evaluation of additions, answers, oral reports, abstract: RN 1.1 - 4.1 - 10 points / 5 points - final assessment: in the form of a credit

Ukrainian