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Biochemical mechanisms of cell damage

Вибіркова дисципліна для ОП

Second

2021/2022

3 Semester

5

PR04. Solve complex problems in the field of biology, generate and evaluate ideas PR06. Analyze biological phenomena and processes at the molecular, cellular, organismal, population-species and biosphere levels in terms of basic general scientific knowledge, as well as using special modern research methods PR07. Describe and analyze the principles of structural and functional organization, mechanisms of regulation and adaptation of organisms to the influence of various factors. PR08. Apply during research knowledge of the peculiarities of the development of modern biological science, the basic methodological principles of scientific research, methodological and methodological tools for conducting research in specialization PR17. Apply modern learning technologies for teaching special subjects

Full-time form

1. Successful mastering of scientific-theoretical and practical material of academic disciplines taught to students of PR "Bachelor". 2. Be able to independently apply knowledge of molecular biology, biochemistry, microbiology, etc. disciplines, perform laboratory and practical work, work with scientific and methodological literature. 3. Have basic skills in working with materials and equipment used in biological and biotechnological laboratories.

"Biochemical mechanisms of cell damage" - a discipline aimed at studying the mechanisms of response to damaging stimuli of various etiologies at the molecular and biochemical levels. The classification, types and principles of action of pathological stimuli on cells are considered. Particular attention is paid to the various stages of development of programmed cell death, the structure and functions of major regulators and mediators involved in the development of stress response in different cell types.

Berg, J. M., Tymoczko, J. L. and Stryer, L. Biochemistry. Freeman, 7th edition, 2011. Lodish, H., Berk, A., Zipursky, S. L., Matsudaira, P., Baltimore, D. and James Darnell, J. Molecular Cell Biology, Freeman, 7th edition 2013. Nelson, D. L. & Cox, M. M. Lehninger Principles of Biochemistry. Freeman, 6th edition, 2013. Ryter, S. W., Cloonan, S. M. & Choi, A. M. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol. Cells 36, 7–16 (2013). Choi, A. M., Ryter, S. W. & Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 368, 651–662 (2013). Yuan, J. & Kroemer, G. Alternative cell death mechanisms in development and beyond. Genes Dev. 24, 2592–2602 (2010). Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G. & Linkermann, A. Molecular mechanisms of regulated necrosis. Semin. Cell Dev. Biol. 35, 24–32 (2014).

Lecture, practice session, seminar, individual work

1. Modular control work 1 - PH 1.1; 1.2. - 30 points / 15 points 2. Modular test work 2 - PH 1.3 - 30 points / 15 points 3. Protocol of practical work / conclusions - RN 2.1; 2.2; 2.3 - 16 points / 8 points 4. Reports and presentations - RN 3.1 - 10 points / 5 points 5. Test work RN 4.1 - 14 points / 7 points - final assessment: in the form of a credit

Ukrainian