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Biochemistry of reactive nitrogen and oxygen

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

5

PR4. Solve complex problems in the field of biology, generate and evaluate ideas. PR7. Describe and analyze the principles of structural and functional organization, mechanisms of regulation and adaptation of organisms to the influence of various factors. PR12. Use innovative approaches to solve complex problems of biology under uncertain conditions and requirements. PR16. Critically comprehend theories, principles, methods in various fields of biology to solve practical problems and problems. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods.

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1. Successful mastering of the courses "Bioorganic Chemistry", "Molecular Biology", "Biochemistry", "Biotechnology". 2. Be able to independently apply knowledge of bioorganic chemistry, biochemistry, biotechnology, etc. disciplines, perform laboratory and practical work, work with scientific and methodological literature. 3. Have basic skills in working with materials and equipment used in biological laboratories.

The course provides professional development of the student and is aimed at forming his competence in understanding the role of reactive nitrogen and oxygen in biological processes. Particular attention is paid to the laws of nitric oxide metabolism and reactive oxygen species in the cell, the role of NO and H 2 O 2 as signaling and regulatory molecules. The pathogenesis of diseases common in human populations is considered from the point of view of impaired metabolism of reactive nitrogen and oxygen and ways to correct it. The directions of selective influence on the corresponding enzymes and processes for the purpose of creation of modern pharmacological preparations are scientifically substantiated.

1. Krauss G. Biochemistry of signal transduction and regulation. – Germany: Wiley-VCH Verlag GmbH & Co. KGaA, Boschstr. 12, 69469 Weinheim, 2014. - 815 p. 2. Helmreich E.J.M. Biochemistry of cell signaling. - Oxford University. press, 2002. - 358 p. 3. Marinho H.S., Real C., Cyrne L., Soares H., Antunes F. Hudrogen peroxide sensing, signaling and regulation of transcription factors, Redox Biol. - 2014. - N 2. - P. 535-562. 4. Levine A.B. Characteristics of the role of nitric oxide and its clinic applications // Cardiology. - 2012. - V. 122, N 1. - P. 55-68.

Lecture, Independent work, Practical work.

- semester assessment: 1. Modular test 1 (remote) - PH 1.1; 1.2. - 20 points / 10 points 2. Modular test work 2 (remote) - PH 1.3; 1.4 - 20 points / 10 points 3. Practical classes - PH 2.1; 2.2; 3.1 - 12 points / 6 points 4. Intermediate control of PH 4.1 - 8 points / 4 points - final assessment: in the form of a credit

Ukrainian