Infopaket

Molecular organization of chromatin

Вибіркова дисципліна для ОП

First

2021/2022

10 Semester

3

PR03. Use theories and laws of mathematics, physics, chemistry and other sciences to solve problems of modern biology. PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the boundaries of subject areas. PR07. Demonstrate knowledge of the structural organization of biological systems at the molecular level of the organization. PR09. Demonstrate knowledge of heredity and variability, molecular mechanisms of conservation and realization of genetic information and importance in evolutionary processes. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology.

External form

Successful mastering of courses "Cytology", "Biochemistry", "Molecular Biology", "Genetics", "Biophysics" Knowledge of the theoretical foundations of biochemistry, molecular biology, genetics and biophysics Ability to independently apply knowledge of molecular biology and other disciplines, use computers and databases, work with scientific literature.

The course is devoted to the basic principles of structural organization of chromatin (chromosomes) in the interphase nucleus of eukaryotic cells, as well as molecular mechanisms of regulation of functional processes in the nucleus at the level of structural rearrangements of chromatin. The structure and conformational mobility of the nucleosome, supranucleosomal levels of chromatin organization, mechanisms of epigenetic heredity, molecular mechanisms of regulation of DNA transcription and replication and structural changes of chromatin underlying such regulation, as well as principles of modern methods of chromatin structure study are considered.

1. Sivolob A.V. Molecular biology. - K .: Publishing and printing center "Kyiv University", 2008, 384 p. 2. Sivolob A.V. Physics of DNA. - K .: Publishing and printing center "Kyiv University", 2011, 335 p. 3. Sivolob A.V., Afanas'eva K.S. Molecular organization of chromosomes. - K.: Publishing and printing center "Kyiv University". 4. Chromatin structure and gene expression: frontiers in molecular biology. S. Elgin, JL Workman, eds. – Oxford: Oxford University Press. - 2002. 5. Chromatin structure and dynamics: state-of-the-art. New Comprehensive Biochemistry, Vol. Thirty-ninth J. Zlatanova, S. H. Leuba, eds. – Amsterdam: Elsevier. – 2004.

Lectures, independent work

Semester assessment: 1. Modular test work1 (remotely): PH 1.1, 1.3, 2.1, 2.2, 2.3 - 20 points / 10 points 2. Modular test work 2: PH 1.2, 1.3, 2.1, 2.2, 2.3 - 20 points / 10 points 3. Presentations, oral presentations, additions: PH 1.1 - 3.1 - 20 points / 10 points Final assessment: in the form of an exam

Ukrainian