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Molecular basis of action of enzymes

Вибіркова дисципліна для ОП

First

2021/2022

7 Semester

3

PR03. Use theories and laws of mathematics, physics, chemistry and other sciences to solve problems of modern biology. PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the borders of subject areas PR05. Use knowledge and demonstrate compliance with the provisions of biological ethics, biological safety and biological protection. PR08. Demonstrate knowledge of fundamental biological processes, structure and functions of living organisms. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR16. Choose methods, algorithms for planning and conducting field, laboratory, clinical and laboratory research, including mathematical methods and software for research, processing and presentation of results.

Full-time form

1. Successful mastering of the courses "Bioorganic Chemistry", "Molecular Biology", "Biochemistry", "General Genetics", "Biotechnology". 2. Be able to independently apply knowledge of bioorganic chemistry, molecular biology, biochemistry, biotechnology, etc. disciplines, perform laboratory and practical work, work with scientific and methodological literature. 3. Have basic skills in working with materials and equipment used in biological and biotechnological laboratories.

The discipline "Molecular basis of enzyme action" includes the study of biochemical and molecular mechanisms of catalysis, modern theories of enzyme-substrate interaction, the relationship between the structure of active centers of enzymes and their catalytic activity, biochemical mechanisms of enzyme regulation. Peculiarities of enzymes functioning are studied, modern data on their structure are generalized, mechanisms of regulation of enzymatic activity are considered. Attention is paid to the applied aspects of the use of enzymes for the development of new drugs aimed at correcting numerous disorders of intracellular biochemical processes.

1. Кравченко О.О., Савчук О.М., Остапченко Л.Т. Основи біотехнології. Навчальний посібник. - К.: ВПЦКНУ. -2019р, 2. Trevor Palmer, Philip L. Bonner ENZYMES: Biochemistry, Biotechnology and Clinical Chemistry Second Edition Published by Woodhead Publishing Limited , 2007, P 431 3. Raksha, N.G., Halenova, T.I., Vovk, T.B., Ishchuk, T.V., Savchuk, O.M., Ostapchenko, L.I. Novel fibrinogenolytic metalloprotease from the antarctic scallop (adamussium colbecki) (Book Chapter) // Nova Science Publishers, Inc. (Advances in Marine Biology), 2018. 4. Nataliia Raksha, Tetiana Halenova, Tetyana Vovk, Oleksii Savchuk and Lydmila Ostapchenko Protease Composition in Tissue Extracts of Hydrobionts from Antarctic Region: Recent Study Current Research Trends in Biological Science 2020, Vol. 1 Chapter 13. DOI: 10.9734/bpi/crtbs/v1

Lecture, individual work

Semester assessment: 1. Modular control work 1 - PH 1.1; 1.2. - 20 points / 10 points 2. Modular control work 2 - PH 1.3; 1.4 - 20 points / 10 points 3. Test work - RN 2.1; 3.1 - 20 points / 10 points - final assessment: in the form of an exam

Ukrainian