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Biophysical mechanisms of cell damage

Вибіркова дисципліна для ОП

First

2021/2022

8 Semester

3

PR03. Use theories and laws of mathematics, physics, chemistry and other sciences to solve problems of modern biology. PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the boundaries of subject areas. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology. PR23.1. Possess (modern) basic biophysical methods in biological research. PR24.1. Have modern methods of information technology in biology. PR25.1. Apply the acquired theoretical knowledge and practical skills to plan and conduct scientific experiments in the field of biophysics.

Full-time form

1. Successful mastering of scientific-theoretical and practical material of academic disciplines taught to undergraduate students, such as "Biophysics", "Biochemistry", "Molecular Biology", "Biophysical principles of regulation of cellular processes", "Membrane biophysics". 2. Be able to independently apply knowledge of cytology, biochemistry, molecular biology, etc. disciplines, work with scientific and methodological literature. 3. Have basic skills in working with materials and equipment used in the biophysical laboratory.

The discipline is devoted to the study of biophysical foundations of cell pathology. Current information on the causes and mechanisms of the development of structural and functional disorders of the cell at the molecular-cellular level is considered. The mechanisms of regulation of cell redox balance, the importance of antioxidant protection in increasing cell resistance to adverse effects, the multilevel nature of antioxidant protection, as well as the issue of free radical damage to cell biomembranes, its internal structures and pathological consequences of such damage. Particular attention is paid to violations of information support of the cell in the development of pathology, namely defects in the functioning of receptors, secondary mediators, signaling mechanisms in various pathologies.

1. Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. Molecular Biology of the Cell, 4th ed. New York, 2000. Chapters: Mechanisms of cell communications, p.879-903; Cytokines, p. 1092-1101; Cell junctions, cell adhesion, extracellular matrix, p. 1131-1204; Cancer, p. 1205- 1267. 2. Lodish H., Berk A., Zipursky S.L., Matsudaira P., Baltimore D., Darnell J.E. Molecular Cell Biology, 4th ed, New York, 2007. Chapter 6. Integrating cells into tissues, Pp. 197-243.

Lecture, individual work

Semester assessment: 1. Modular control work 1 - PH 1.1; PH 1.2 - 15 points / 7.5 points 2. Modular control work 2 - PH 1.3; PH 1.4 - 15 points / 7.5 points 3. Evaluation of abstracts on the selected topic RN 1.1- 3.1 - 10 points / 5 points 4. Evaluation of oral answers and additions RN 1.1- 3.1 - 20 points / 10 points - final assessment: in the form of an exam

Ukrainian