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Electrobiophysics and biophysics of ion channels

Вибіркова дисципліна для ОП

First

2021/2022

8 Semester

3

PR03. Use theories and laws of mathematics, physics, chemistry and other sciences to solve problems of modern biology. PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the boundaries of subject areas. PR07. Demonstrate knowledge of the structural organization of biological systems at the molecular level of the organization. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology. PR21. Solve applied problems of biology by appropriate methods. PR23. Possess (modern) basic biophysical methods in biological research. PR24. Have modern methods of information technology in biology.

Full-time form

1. Successful mastering of scientific-theoretical and practical material of academic disciplines taught to students of educational level "Bachelor", in particular "Biophysics", "Biochemistry", "Physiology of man and animals", "Molecular Biology". 2. Be able to independently apply knowledge of biophysics, biochemistry, molecular biology and other disciplines, work with scientific and methodological literature. 3. Have the skills to work with computers, materials and equipment used in biological laboratories.

The subject of the discipline is the study of electrical properties of cells and tissues, physicochemical processes that underlie electrogenesis, including biophysical and molecular mechanisms of formation and maintenance of transmembrane ion gradients and transmembrane ion transport. The main electrophysiological methods of multicellular preparations and isolated cells, principles of modern robotic patch-terminal systems, basic principles of classical ion channel biophysics, molecular biophysics and ion channel physiology, modern classification of potential- and ligand-controlled ion channels and their biophysical functions and their biophysical functions are considered. and molecular mechanisms of calcium homeostasis and signaling. In the future, the acquired knowledge and skills in the field of "Electrobiophysics and biophysics of ion channels" can be used in research in the field of biophysics and in interdisciplinary research.

1. Shuba MF, Davydovskaya TL, Prylutsky YI, Zholos OV, Bogutskaya KI Electrobiophysics. - Kyiv: Phytosocial Center, 2002. - 152 p. 2. Davydovska TL, Miroshnichenko MS, Prylutsky YI, Zholos OV (2006). Theoretical and experimental foundations of biophysics of electrical phenomena. K .: Phytosocial center, 190 p. 3. Shuba YM Fundamentals of molecular physiology of ion channels. - К.: Наук. Opinion, 2010. - 447 c. 4. Hille B. Ion channels of excitable membranes, 3rd Edition. - Sunderland, Massachusetts, USA: Sinauer Associates, 2001. - 814 p. 5. Kandel E.R., Schawartz J.H., Jessel T.M., Siegelbaum S.A., Hudspeth A.J. Principals of neural science, 5th Edition. - The McGeaw-Hill Companies, Inc., 2013. - 1760 p.

Lecture, individual work

Current evaluation / control: 1. Modular control work 1 - PH 1.1; 1.2. - 15 points / 9 points 2. Modular control work 2 - PH 1.3; 1.4– 15 points / 9 points 3. Presentation - PH 3.1 - 10 points / 6 points 4. Summary - RN 4.1 - 10 points / 6 points 5. Intermediate testing of pH 2.1; 2.2 - 10 points / 6 points - final assessment: in the form of an exam

Ukrainian