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Fundamentals of toxicology and assessment of toxicological states

Вибіркова дисципліна для ОП

First

2025/2026

5 Semester

4

PRN 2. Determine the qualitative and quantitative composition of substances and their mixtures. Demonstrate the use of knowledge about morphological changes in tissues and organs for the diagnosis of pathological conditions, identify erroneous results and take measures to correct them. PRN 4. Understand the physical and chemical principles of staining and apply appropriate methods in laboratory research.

1. Have basic knowledge of analytical, biological and medical chemistry, in particular regarding the properties of chemical compounds and their interaction with biological systems. 2. Have an idea of ​​the basics of pharmacology, in particular the effect of chemical substances on the body and the routes of their entry. 3. Have the basics of human physiology and pathophysiology, understand the mechanisms of organ and system dysfunction. 4. Master the basic principles of clinical laboratory diagnostics, including the principles of laboratory research and evaluation of their results.

The elective discipline "Fundamentals of Toxicology and Assessment of Toxicological States" is aimed at forming in students a systematic understanding of the sources, classification and mechanisms of action of toxic substances, the pathogenesis of acute and chronic intoxications, as well as the principles of laboratory diagnostics of toxicological states. The course examines the main groups of toxicants, their effect on organs and systems, laboratory markers of intoxications, methods of selection and preparation of biological material, interpretation of research results and the role of a laboratory diagnostics specialist in the detection and monitoring of toxic lesions. Special attention is paid to clinical and laboratory approaches to assessing the severity of intoxications and the principles of emergency care.

Bardov V.G. Hygiene and ecology: textbook / Ed. V.G. Bardov. Vinnytsia: Nova Kniga, 2020. 600 p. 2. Bondar V.S. Toxicological chemistry: Lecture notes / V.S. Bondar, O.O. Mamina, S.A. Karpushina et al. Kh.: Publishing house of the National University of Physics and Technology, Golden Pages, 2018. 160 p. 3. Varbanets L.D., Zdorovenko G.M., Knirel Yu.A. Methods of studying endotoxins - K.: Naukova Dumka, 2016. - 237 p. 4. Voronov S.A., Yu.B. Stetsyshyn, Yu.V. Panchenko, V.P. Vasyliev; edited by prof. S.A. Voronova. - Lviv: Lviv Polytechnic Publishing House, 2019. - 316 p.

Lectures, Laboratory classes, individual work

semester assessment: 1. Modular test paper 1 - RN 1.1-1.5 – 30 points / 15 points 2. Modular test paper 2 - RN 2.1-2.4 – 30 points / 15 points 3. Practical work - RN 2.1 – 3.3 – 30 points / 15 points 4. Reports - RN 2.1 - 3.3 – 10 points / 5 points - final assessment: in the form of a credit

ukrainian