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Macromolecules of bioorganic nature. Part III.

Вибіркова дисципліна для ОП

First

2025/2026

10 Semester

3

PR02. Apply modern information technologies, software and Internet resources for information support of professional activities. PR04. Communicate orally and in writing on professional issues using scientific terms accepted in the professional environment, in the state and foreign languages. PR07. Possess methods of self-education and self-improvement. Be able to design a trajectory of professional growth and personal development, applying the acquired knowledge. PR08. Know and understand the basic terms, concepts, theories and laws in the field of biological sciences and at the border of subject areas. PR11. Understand the structural organization of biological systems at the molecular level. PR12. Demonstrate knowledge of the structure, vital processes and functions of living organisms, understand the mechanisms of regulation of physiological functions to maintain homeostasis of biological systems.

External form

1. Successful completion of the courses "Bioorganic Chemistry", "Biochemistry", "Molecular Biology". 2. Be able to independently apply previously acquired knowledge in molecular biology, biochemistry and other disciplines, search for new scientific data, work with scientific and methodological literature. 3. Possess basic skills in working with materials and equipment used in biological and biotechnological laboratories.

The discipline “Macromolecules of Bioorganic Nature (Part 3)” studies the role of carbohydrates in the structure of intracellular biopolymers. The third part of the discipline “Macromolecules of Bioorganic Nature” examines the main classes of carbohydrates, glycans, sialic acids, hyaluronates and carbohydrate-bound molecules. The structure of the main classes of the above-mentioned molecules is described, the main metabolic processes associated with glycans and carbohydrate-bound molecules, as well as their derivatives, are characterized, and the mechanisms of the development of pathologies resulting from impaired synthesis or degradation are considered. This discipline highlights the methods of diagnosing these diseases, protocols for their diagnosis and treatment. Demonstrates an analysis of modern challenges in science aimed at improving the diagnosis and treatment of congenital glycosylation diseases. Already available drugs, such as heparin, erythropoietin, and some anti-influenza drugs, have proven effective, leading to the consideration of glycans as a new class of drugs. In addition, scientists busy searching for new drugs to fight cancer believe that glycobiology opens up new possibilities for them. Anticancer, anti-inflammatory, and anti-infective drugs with novel mechanisms of action are currently in clinical trials. They may improve or complement existing therapeutic approaches.

1. Fundamentals of Glycobiology / Ed. N. Sibirna – Lviv: Ivan Franko National University, 2015. – 492 p. 2. Biochemistry: textbook / Ed. L.I. Ostapchenko – Kyiv: Publishing and Printing Center “Kyiv University”, 2012. – 796 p. 3. Varki A., Cummings R.D., Esko J.D. et al. Essentials of Glycobiology, 4th edition. – Cold Spring Harbor Laboratory Press. – 2022. – 859 p. 4. Patel V.B. Molecular Nutrition: Carbohydrates. – Academic Press. – 2019. – 442 p. 5. Ostapchenko L.I., Rybalchenko V.K. "Biological and Bioorganic Chemistry" K: Publishing and Printing Center "Kyiv University", 2015, 917 p.

Lectures, independent work

Semester assessment: Modular test 1 (remotely) – RN 1.1- 3.1 – 30 points/ 15 points Modular test 2 – RN 1.1- 3.1 – 30 points/ 15 points Summary assessment (semester test): in the form of an exam