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Biochemical mechanisms of cell damage

Вибіркова дисципліна для ОП

Second

2025/2026

3 Semester

4

PR04. Solve complex problems in the field of biology, generate and evaluate ideas. PR06. Analyze biological phenomena and processes at the molecular, cellular, organismal, population-species and biosphere levels in terms of basic general scientific knowledge, as well as using special modern research methods. PR07. Describe and analyze the principles of structural and functional organization, mechanisms of regulation and adaptation of organisms to the influence of various factors. PR08. Apply during research knowledge of the peculiarities of the development of modern biological science, the basic methodological principles of scientific research, methodological and methodological tools for conducting research in specialization. PR17. Apply modern learning technologies for teaching special subjects.

Full-time form

1. Successful completion of the theoretical and practical components of the following courses offered to first-year Master’s students: "Methodology and Organization of Scientific Research with Fundamentals of Intellectual Property", "Methods of Modern Biological Research", and "Biochemistry of Macromolecular Compounds". 2. Ability to independently apply knowledge acquired through various bachelor’s-level courses, work with scientific and educational-methodological literature, and systematize the information obtained. 3. Have basic skills in working with materials and equipment used in biological and biotechnological laboratories.

"Biochemical mechanisms of cell damage" - a discipline aimed at studying the mechanisms of response to damaging stimuli of various etiologies at the molecular and biochemical levels. The classification, types and principles of action of pathological stimuli on cells are considered. Particular attention is paid to the structure and functions of the major regulatory factors involved in the development of responses to stress and pathological stimuli at the subcellular and cellular levels.

1. Berg, J. M., Tymoczko, J. L. and Stryer, L. Biochemistry. Freeman, 7th edition, 2011. 2. Lodish, H., Berk, A., Zipursky, S. L., Matsudaira, P., Baltimore, D. and James Darnell, J. Molecular Cell Biology, Freeman, 7th edition 2013. 3. Nelson, D. L. & Cox, M. M. Lehninger Principles of Biochemistry. Freeman, 6th edition, 2013. 4. Ryter, S. W., Cloonan, S. M. & Choi, A. M. Autophagy: a critical regulator of cellular metabolism and homeostasis. Mol. Cells 36, 7–16 (2013). 5. Choi, A. M., Ryter, S. W. & Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 368, 651–662 (2013). 6. Yuan, J. & Kroemer, G. Alternative cell death mechanisms in development and beyond. Genes Dev. 24, 2592–2602 (2010). 7. Galluzzi, L., Kepp, O., Krautwald, S., Kroemer, G. & Linkermann, A. Molecular mechanisms of regulated necrosis. Semin. Cell Dev. Biol. 35, 24–32 (2014).

Lectures, practice sessions, seminars, individual work

1. Modular control work 1 - PH 1.1; 1.2. - 30 points / 15 points 2. Modular test work 2 - PH 1.3 - 30 points / 15 points 3. Protocol of practical work / conclusions - PH - 2.1; 2.2; 2.3 - 16 points / 8 points 4. Reports and presentations - PH - 3.1 - 10 points / 5 points 5. Report - PH - 4.1 - 14 points / 7 points - final assessment: in the form of a credit

Ukrainian