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Genome instability

Вибіркова дисципліна для ОП

Second

2025/2026

2 Semester

4

PR19.5. Apply modern specialized methods of molecular and population genetics, as well as genetic analysis. PR20.5. Develop a systematic approach to the analysis and interpretation of new findings on the organization and functioning of living systems at the molecular, cellular, organismal, and population levels, drawing on advanced knowledge acquired through professionally oriented practical courses.

Full-time form

1. Successful completion of the courses "Molecular Biology", "Microbiology", "Immunology", "Virology", "General Genetics", "Biochemistry", "Human Genetics", "Cancer Genetics", "Genomics", "Eukaryotic Chromosomes", and "Molecular Organization of Chromatin". 2. Knowledge of the theoretical foundations of chemistry, physics, molecular biology, cell biology, and related disciplines; ability to apply theoretical knowledge acquired in these disciplines to solve practical problems. 3. Basic skills in working with scientific electronic databases and scientific literature, and the ability to perform systems analysis.

"Genome instability" considers the phenomenon of genome instability as a fundamental and integral property. Attention is paid to the general causes of genome instability, molecular repair mechanisms that ensure genome stabilization, the role of specific genomic sequences, mobile genetic elements, chromatin structures in the stabilization and destabilization of the genome. Attention is paid to the mechanisms of genome destabilization in normal and pathological processes. The role of genome instability in micro- and macroevolution is discussed.

1. Афанасьєва К.С., Проніна О.В., Рушковський С.Р. Методичні вказівки до спецпрактикуму “Нестабільність геному” для студентів біологічного факультету // Київ: Фітосоціоцентр, 2006. 2. Genome Stability. From Virus to Human Application // Ed. Kovalchuk I., Kovalchuk O. - Academic Press, 2016 3. DNA Repair Disorders // Ed. Nishigori Ch., Sugasawa K. Springer Verlag, 2019. 4. Khanna K.K., Shilo Y. The DNA Damage Response - Springer Verlag, 2009. 5. Miller W.J., Capy P. Mobile Genetic Elements - Humana Press, 2004. 6. The Chemical Biology of DNA Damage // Ed.. Geacintov N. and Broyde S. - WILEY VCH Verlag GmbH & Co., 2010.

Lectures, laboratory work, practical work, independent work

1. Modular test work1: PH 1.1 - 2 .5 – 35 points / 15 points (block of topics of Section 1) 2. Modular test work 2: PH 1.1 - 2.5 – 35 points / 15 points (block of topics of Section 2) 3. Evaluation of laboratory work: PH 2.1 - 3.1 - 20 points / 10 points 4. Evaluation of additions, answers, oral reports, Solving research problems and preparing presentations, abstract: PH 1.1 - 4.1 - 10 points / 5 points - final assessment: in the form of a credit

Ukrainian