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Physical chemistry of biopolymers

Вибіркова дисципліна для ОП

Second

2025/2026

2 Semester

5

PR20.5. Develop a systematic approach to the analysis and interpretation of new findings on the organization and functioning of living systems at the molecular, cellular, organismal, and population levels, drawing on advanced knowledge acquired through professionally oriented practical courses.

Full-time form

1. Successful mastering of the courses "Biochemistry", "Molecular Biology", "Biophysics" 2. Knowledge of theoretical foundations of mathematics, physical chemistry, molecular physics, biochemistry, molecular biology and biophysics 3. Ability to independently apply knowledge of molecular biology, etc. disciplines, perform laboratory and practical work, work with scientific literature.

The course is devoted to the basic principles of structural organization, physical behavior and functioning of biological macromolecules - nucleic acids and proteins. The structure and conformational mobility of biopolymers, mechanisms of stabilization of their spatial structure, regularities of cooperative structural transformations, electrostatic, hydrophobic and other noncovalent interactions in biopolymers, basics of polymer physics, topology of circular DNA, principles of modern methods of biopolymers research are considered.

1. Lesk, A.M. Introduction to protein architecture: the structural biology of proteins. – Oxford : Oxford University Press, 2001. 2. Kessel, A. and Ben-Tal, N. Introduction to proteins: structure, function, and motion. Boca Raton FL : CRC Press, 2018. 3. Сиволоб А.В. Молекулярна біологія. – К. : Видавничо-поліграфічний центр “Київський університет“, 2023, 511 с. 4. Сиволоб А.В. Фізика ДНК. – К. : Видавничо-поліграфічний центр “Київський університет“, 2011, 335 с. 5. Bloomfield V.A., Crothers D.M., Tinoco I. Nucleic acids: structures, properties and functions. – Sausalito, CA, USA : University Science Books, 2000.

Lectures, practical work, independent work

1. Modular test 1: PH 1.1 - 15 points / 7 points 2. Modular test work 2: PH 1.2 - 15 points / 7 points 3. Practical works: PH 2.1, 2.2, 3.1 - 20 points / 10 points 4. Evaluation of additions, answers, presentations / oral reports, abstract: PH 1.1 - 4.1 - 10 points / 5 points - final assessment: in the form of an exam

Ukrainian