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Stem cells

Вибіркова дисципліна для ОП

Second

2025/2026

2 Semester

4

PR19.12 Apply specialized professional knowledge and practical skills to address research and practical tasks in the field of reproductive biology, and develop practical recommendations based on research findings in reproductive biology and related sciences. PR20.12 Develop a systematic approach to the analysis and interpretation of new findings on the characteristics of ontogenetic development under normal and pathological conditions, drawing on advanced knowledge acquired through professionally oriented practical courses.

Full-time form

1. Successful mastering of disciplines "Cytology", "Histology", "Biology of individual development", "Molecular biology", "Biochemistry", "Genetics", "Human and animal physiology", "Immunology". 2. Ability to independently apply knowledge of cytology, histology, molecular biology, biochemistry, genetics, etc. disciplines for solving specific scientific and practical problems; work with scientific and scientific-methodical literature. 3. Possession of basic skills of systems analysis.

The course focuses primarily on developing students’ theoretical understanding and practical skills related to methods for isolating and culturing stem cells of various origins. It provides a clear understanding of the processes of proliferation, cell determination, and differentiation in animal cells; identifies the major stem cell niches and the pathways and mechanisms of stem cell migration; and examines the general and specific characteristics of stem cells from different sources, including embryonic, fetal, and adult (tissue-specific) stem cells. The course “Stem Cells” opens up opportunities for research into and the application of stem cells from various sources to address practical challenges in regenerative and reproductive medicine.

1. Сукач О.М., Іонов І.А., Всеволодська С.О. Вступ до біології стовбурової клітини. О г л я д/ Біорізноманіття, екологія та експериментальна біологія, 2021. 23, №2. С.47-60. 2. Mummery Christine L., van de Stolpe Anja, ... Clevers Hans Stem Cells. Scientific Facts and Fiction/ Book, Third Edition, 2021. -411 p. 3. Essentials of Stem Cell Biology /Ed. by: RLanza &A.Atala - Book• Third Edition • 2014/ - 680 p. 4. Білько, Д. І. Методи культури клітин і тканин у біології, біотехнології та. / Д. І. Білько. – Київ: НаУКМА, 2017. – 88 с. 5. Рибальченко Т.В., Кузнєцова Г.М., Дзержинський М.Е., Рибальченко В.К.. Механізми клітинної диференціації, – Київ : ВПЦ "Київський університет", 2017. – 383 с. 6. Stepanov YV, Golovynska I, Ostrovska G, et al. Human mesenchymal stem cells increase LLC metastasis and stimulate or decelerate tumor development depending on injection method and cell amount. Cytometry A. 2024;105(4):252-265.

Lectures, independent work, practical classes.

- semester assessment: 1. Modular test 1. - PH 1.1 -4.1– 20 points / 10 points 2. Modular test 2. - PH 1.2- 4.1 - 20 points / 10 points 3. Practical classes - PH 2.1; 2.2, 2.3, 2.4, 3.1, 3.2 - 8 points / 4 points 4. Preparation of the presentation / report РН1.1- 4.1 -8 points / 4 points 5. Oral answers / additions PH 1.1-4.1 - 4 points / 2 points - final assessment: in the form of an exam

Ukrainian