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Molecular basis of enzyme action

Вибіркова дисципліна для ОП

First

2025/2026

9 Semester

3

PR03. Plan, perform, analyze data and present the results of experimental research in the field of biology. PR05. Demonstrate skills in evaluating unpredictable biological problems and thoughtfully choosing ways to solve them. PR06. Apply models, methods and data of physics, chemistry, ecology, mathematics in the process of learning and ensuring professional activity. PR08. Know and understand the basic terms, concepts, theories and laws in the field of biological sciences and at the border of subject areas. PR09. Follow the provisions of biological ethics, rules of biological safety and biological protection in the process of learning and professional activity. PR12. Demonstrate knowledge of the structure, vital processes and functions of living organisms, understand the mechanisms of regulation of physiological functions to maintain homeostasis of biological systems.

External form

1. Successful mastering of the courses "Bioorganic Chemistry", "Molecular Biology", "Biochemistry", "General Genetics", "Biotechnology". 2. Be able to independently apply knowledge of bioorganic chemistry, molecular biology, biochemistry, biotechnology, etc. disciplines, perform laboratory and practical work, work with scientific and methodological literature. 3. Have basic skills in working with materials and equipment used in biological and biotechnological laboratories.

The discipline "Molecular basis of enzyme action" includes the study of biochemical and molecular mechanisms of catalysis, modern theories of enzyme-substrate interaction, the relationship between the structure of active centers of enzymes and their catalytic activity, biochemical mechanisms of enzyme regulation. Peculiarities of enzymes functioning are studied, modern data on their structure are generalized, mechanisms of regulation of enzymatic activity are considered. Attention is paid to the applied aspects of the use of enzymes for the development of new drugs aimed at correcting numerous disorders of intracellular biochemical processes.

1. Kravchenko O.O., Savchuk O.M., Ostapchenko L.I. Basics of biotechnology. Tutorial. - K.: VOC KNU. - 2019 2. Trevor Palmer, Philip L. Bonner ENZYMES: Biochemistry, Biotechnology and Clinical Chemistry Second Edition Published by Woodhead Publishing Limited, 2007, P. 431. 3. Raksha, N.G., Halenova, T.I., Vovk, T.B., Ishchuk, T.V., Savchuk, O.M., Ostapchenko, L.I. Novel fibrinogenolytic metalloprotease from the antarctic scallop (adamussium colbecki) (Book Chapter) // Nova Science Publishers, Inc. (Advances in Marine Biology), 2018. 4. Nataliia Raksha, Tetiana Halenova, Tetyana Vovk, Oleksii Savchuk and Lydmila Ostapchenko Protease Composition in Tissue Extracts of Hydrobionts from Antarctic Region: Recent Study Current Research Trends in Biological Science 2020, Vol. 1 Chapter 13. DOI: 10.9734/bpi/crtbs/v1

Lecture, independent work

Semester assessment: 1. Modular test 1 (remote) - PH 1.1; 1.2. - 20 points / 10 points 2. Modular control work 2 - PH 1.3; 1.4 - 20 points / 10 points 3. Test work - PH 2.1; 3.1 - 20 points / 10 points Final assessment: in the form of an exam

Ukrainian