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Molecular mechanisms of allergic reactions

Вибіркова дисципліна для ОП

First

2025/2026

10 Semester

3

PR01. Understand the social and economic consequences of implementing the latest developments in the field of biology in professional activities. PR08. Know and understand the basic terms, concepts, theories and laws in the field of biological sciences and at the border of subject areas. PR11. Understand the structural organization of biological systems at the molecular level. PR16. Know the structure and functions of the immune system, cellular and molecular mechanisms of immune reactions, their regulation, genetic control; types of immunity and methods for assessing the immune status of the organism. PR28.7. Solve problems of a fundamental and applied nature in the field of immunology.

External form

1. Successful mastery of scientific, theoretical and practical material of academic disciplines taught to students of the "Bachelor" educational level. 2. Knowledge of the theoretical foundations of anatomy, physiology, cytology, general immunology and biochemistry. 3. Knowledge of the theoretical foundations of laboratory research of indicators of the state of the immune system. 4. Possession of elementary skills in the application of immunological methods to establish violations of the functioning of various parts of the immune system. 5. Use of special literature to interpret the results obtained during the study of immunological indicators in various diseases.

The discipline highlights issues related to molecular mechanisms of implementation of various types of hypersensitivity reactions. The course is based on the classification of various types of hypersensitivity according to the mechanisms of immunopathogenesis. An important place is given to the issues of the features of the implementation of immune-mediated damage to tissues and organs of the body, cellular and mediator mechanisms of immunopathological reactions in reagent, cytotoxic, immune complex inflammation, as well as in the development of granulomatous reactions in various pathologies. Considerable attention is paid to the biochemical aspects of the implementation of allergic inflammation, the participation of various pro-inflammatory and anti-inflammatory mediators in the interaction of immune system cells and the role of immune system cells in the regulation of homeostasis of the body, the unique features of immunoregulatory mechanisms in ensuring the normal functioning of the body.

1. Immunology. Textbook./Edited by Pasteur E.U./- Kyiv: Publishing and Printing Center "Kyiv University", 2011. – 911 p. 2. Fundamentals of Immunology: Functions and Disorders of the Immune System: A Manual, Translated from the 6th Edition./Abdul Abbas, Andrew Lichtman, Shiv Pillai, ed. V.V. Chop’yak - Kyiv: VSV "Medicine"., 2020.-336 p. 3. Voronenko Y.V., Pukhlyk B.M., Kuznetsova L.V. et al. Allergology. Textbook.- Kyiv: 2008.-295 p. https://allergo.kiev.ua/pdf 4. Chop’yak V.V. Clinical Immunology and Allergology: Teaching. manual.- K: VSV: "Medicine", 2017. - 224 p.

Lecture, independent work

Semester assessment: 1. Modular test 1 (remotely): РН 1.1 – 3.1 –10/5 points; 2. Modular test 2: РН 1.1 - 3.1 - 30/15 points; 4. Essay: РН1.1 – 1.5, 3.1 – 20 points/ 10 points. Final assessment: in the form of an exam

Ukrainian