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Molecular mechanisms of cell differentiation

Вибіркова дисципліна для ОП

Second

2023/2024

2 Semester

5

PR2. Use libraries, information databases, and Internet resources to find the necessary information. PR4. Solve complex problems in the field of biology, generate and evaluate ideas. PR6. Analyze biological phenomena and processes at the molecular, cellular, organismal, population and biosphere levels in terms of fundamental general scientific knowledge, as well as using special modern research methods. PR10. To present the results of scientific work in writing (in the form of a report, scientific publications, etc.) and orally (in the form of reports and report defense) using modern technologies, to argue their position in a scientific discussion.

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1. Successful completion of the following courses: "Biology of Individual Development", "Cytology", "Genetics", "Molecular Biology", "Biochemistry", . 2. Knowledge of theoretical foundations, molecular biology, biochemistry, genetics, cytology, embryology, cell biology. 3. Ability to independently apply knowledge of the above disciplines, perform laboratory and practical work, work with scientific literature and electronic databases, predict and critically evaluate research results, ability to systematic analysis.

The course covers an overview of current information on the mechanisms of cell determination and differentiation at the molecular level. During the course, students are introduced to the basic laws and molecular mechanisms of cell determination and differentiation, as well as the principles of selective gene expression (molecular determinants of development, homeotic genes, cascades of intercellular and intermolecular interactions in the regulation of selector gene expression, changes in chromatin structure and epigenetic control during cell differentiation, etc.) Particular attention is paid to stem cell genetics, neurogenesis, features of cell dedifferentiation, and pathologies associated with disorders of coordination and control of cell differentiation.

1. Afanasieva K.S. Regulation of gene expression. Lecture notes, Kyiv, 2024. 2. Syvolob A.V. Molecular biology. - Kyiv: Kyiv University. - 2023 7 3. Syvolob A.V., Afanasieva K.S. Molecular organization of chromosomes. - Kyiv: Kyiv University. - 2013, 287 p. 4. Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. Molecular Biology of the Cell. Fifth Edition - New York, Garland Science, 2007.

Lectures, practical work, independent work.

- semester assessment: 1. Modular control work1: WP 1.1-1.3 - 40 points/20 points 2. Module test work 2: WP 1.1-1.3 - 30 points/15 points 3. Solving research problems: PH 2.1 - 4.1 - 10 points/5 points 4. Evaluation, presentations, oral/written answers and additions: ELO 1.1 - 4.1 - 20 points/10 points - Final assessment: in the form of a test

Ukrainian