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Eukaryotic chromosomes

Вибіркова дисципліна для ОП

First

2023/2024

7 Semester

3

PR06. Apply models, methods and data of physics, chemistry, ecology, mathematics in the process of learning and ensuring professional activity PR07. To have techniques of self-education and self-improvement. Be able to project the trajectory of professional growth and personal development, applying the acquired knowledge. PR08. Know and understand basic terms, concepts, theories and laws in the field of biology sciences and on the border of subject areas. PR11. Understand the structural organization of biological systems at the molecular level. PR13. To know the mechanisms of preservation, implementation and transmission of genetic information and their importance in evolutionary processes. PR17. Understand the role of the evolutionary idea of the organic world.

Full-time form

1. Successful completion of the courses "General Genetics", "Molecular Biology", "Biochemistry", "Cytology", as well as familiarization with selected sections of the biology of individual development, evolution, taxonomy. 2. Knowledge of the theoretical foundations of chemistry, physics, molecular biology, cell biology, etc.; the ability to use theoretical knowledge from these disciplines to solve practical problems. 3. Possession of basic skills of working with scientific electronic databases, scientific literature and ability to system analysis.

The discipline is a basic genetic course, which is devoted to the study of the principles of molecular organization of chromosomes of eukaryotic cells and patterns of control of their behavior in the cell cycle. Mechanisms of chromatin fibril compaction, molecular organization of centromeric, telomeric and subtelomeric regions of chromosomes are considered, principles of cellular control of chromosome segregation during divisions are demonstrated. The variety of types of structural organization of eukaryotic chromosomes is covered, and modern principles of molecular evolution of karyotypes are considered. Particular attention is paid to genetic pathologies associated with dysfunction of the chromosomal apparatus of the cell and disorders of cell cycle control.

1. Сиволоб А.В., Афанасьєва К.С. Молекулярна організація хромосом. – К.: Видавничо-поліграфічний центр “Київський університет“, 2014. 2. Сиволоб А.В. Молекулярна біологія. – К. : Видавничо-поліграфічний центр “Київський університет“, 2023. 3. Методичні вказівки до спецпрактикуму «Хромосоми еукаріотів». Для студентів біологічного факультету / упоряд. Афанасьєва К.С., Проніна О.В., Рушковський С.Р. – Київ: «Фітосоціоцентр», 2007 р. – 20 с . 4. Chromatin structure and dynamics: state-of-the-art. New Comprehensive Biochemistry, Vol. 39. J.Zlatanova, S.H.Leuba, eds. – Amsterdam: Elsevier. – 2004. 5. Chromosome Structure and Aberrations. Bhat T.A, Wani A.A., eds. – India: Springer. – 2017. 6. Lodish H., Berk A., Zipursky S.L., et al Molecular cell biology 4th edition – W.H. Freeman and company, 2001, 1084 р. 7. Samner, A.T. Chromosomes: organization and function. – Oxford : Blackwell Science, 2003.

Lecture, individual work

Semester assessment: 1. Modular test work1: PH 1.1 - 1.3, 2.1, 2.4 - 20 points / 10 points (topic block Section 1) 2. Modular test work 2: PH 1.3 - 1.5, 2.2-2.4 - 20 points / 10 points (topic block Section 2) 3. Solution of research problems: PH 1.1 - 3.1 - 10 points / 5 points 4. Evaluation of additions, answers: RN 1.1 - 3.1 - 10 points / 5 points - final assessment: in the form of an exam

Ukrainian