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Modern physicochemical methods in genetics

Вибіркова дисципліна для ОП

First

2023/2024

6 Semester

3

PRO4. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the boundaries of subject areas. PRO7. Demonstrate knowledge of the structural organization of biological systems at the molecular level of the organization. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR16. Choose methods, algorithms for planning and conducting field, laboratory, clinical and laboratory research, including mathematical methods and software for research, processing and presentation of results. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology. PR19. Solve applied problems of biology by appropriate methods. PR21.3. Possess modern genetic and molecular methods in biological research.

Full-time form

1. Successful mastering of the courses "Genetics", "Molecular Biology", "Biochemistry", "Biophysics". 2. Knowledge of the theoretical foundations of chemistry, physics, genetics, biochemistry and biophysics. 3. Possession of basic skills in working with laboratory equipment, the ability to perform laboratory and practical work, work with scientific literature. 4. Ability to work in Excel and Original programs, skills in working with electronic databases.

The course is devoted to the study of the principles of modern physicochemical research methods and features of their application in the analysis of biological macromolecules and interactions between them. Possibilities and limitations of the basic physical and chemical methods, principles of a choice of a method concerning the purpose of research are shown. Covers methods that can be used in conducting research in related sciences and in interdisciplinary projects, and which require in-depth knowledge of the discipline. Particular attention is paid to modern physico-chemical methods used in the diagnosis and prognosis of genetic diseases in medical practice in Ukraine and around the world. In the course of studying the discipline the practical application and significance of certain methods in molecular and medical genetics are given or demonstrated.

1. Афанасьева К.С. Фізичні методи в молекулярній генетиці. Практикум. К. : Видавничо- поліграфічний центр "Київський університет", 2016, 127 с. 2. Остапченко Л.І. Рибальченко В.К. Біологічна і біоорганічна хімія. В 2-х т. - К. : Видавничо-поліграфічний центр "Київський університет", 2014, 1043 с. 3. Сиволоб А.В. Молекулярна біологія. - К.: Видавничо-поліграфічний центр "Київський університет", 2008, 384 с. 4. Serdyuk LR., Zaccai N.R., Zaceai J. Methods in molecular biophysics - Cambridge: Cambridge University Press, 2007, 1120 p. 5. Rautenstrauss B.W., Liehr T. FISH technology. — Berlin : Springer, 2012, 494 p.

Lecture, individual work

Semester assessment: 1. Modular tests 1 and 2: PH 1.1 - 2.3-- 50 points / 25 points 2. Solution of research problems: RN 2.1 - 3.1 - 5 points / 2.5 points 4. Evaluation of oral and written answers: RN 1.1 - 3.1 - 5 points / 2.5 points - final assessment: in the form of an exam

Ukrainian