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Fundamentals of quantum biochemistry

ОК 3

Обов’язкова дисципліна для ОП

Second

2023/2024

1 Semester

3

To know the structure and functions of the main classes of biomolecules, microscopic mechanisms of photochemical processes and their role in the functioning of living organisms. Know the physical essence and limits of applicability of the most important physicochemical models explaining the structure and interaction of biomolecules To be able to calculate the thermodynamic characteristics of biochemical transformations, establish a connection between the structure of biomolecules and the methods of their functioning. Be able to analyze the impact of quantum mechanical effects on the structural and energetic properties of biomolecules and biochemical transformations involving them.

Full-time form

1. Know the laws of classical and quantum mechanics, thermodynamics and statistical physics. 2. To be able to apply the knowledge gained from the courses of quantum mechanics, molecular and atomic physics. 3. To have the skills to apply the methods of thermodynamics and molecular physics.

The subject of study of the academic discipline is the relationship between fundamental physical laws and basic mechanisms of biochemical processes in living organisms. The goal is to gain knowledge about the manifestations of quantum mechanical phenomena that determine the structure and mutual transformation of molecules and their complexes in biologically important objects. The educational task consists in studying the structure and functions of biomolecules and those physical processes and phenomena that accompany their participation in biochemical processes and transformations.

1. K.B. Yatsimirsky, V.K. Yatsimirsky. Chemical call: Pdruchnik // Kiev: Vishcha school, 1993. - 309 p. 2. D.L. Nelson, M.Cox. Lehninger Principles of Biochemistry: International Edition // Macmillan Learning, 2021. – 1248 p. 3. B.Fertig. Metabolism and Medicine: The Physics of Biological Engines // CRC Press, 2021. - 338 p. 4. S.I. Sandler. Chemical, Biochemical, and Engineering Thermodynamics // Wiley, 2020. - 960 p. 5. E.L. Albuquerque, U.L. Fulco, E. W. S. Caetano, V. N. Freire. Quantum Chemistry Simulation of Biological Molecules // Cambridge University Press, 2021. - 434 p. 6. A. Braun. Quantum Electrodynamics of Photosynthesis: Mathematical Description of Light, Life and Matter //De Gruyter; 2020. - 838 p. 7. S.Zdravković, D. Chevizovich. Nonlinear Dynamics of Nanobiophysics // Springer, 2022. - 360 p. 8. T.M. Nordlund, P.M. Hoffmann. Quantitative Understanding of Biosystems: An Introduction to Biophysics // CRC Press, 2019. - 632 p.

The total volume is 90 hours, including: lectures – 30 hours; individual work - 60 hours

Student evaluation forms: - semester assessment: 1. Modular control work on topic 1 – 20 points/ 12 points 2. Modular control work on topic 2 – 20 points/ 12 points 3. Individual task of processing the educational material and presenting the result in the form of a report - 20 points / 12 points Module 1: assessment for the modular control work on the topic "Structure and functions of biomolecules" - 20 points (marginal assessment 12 points). Module 2: evaluation for the performance of individual (home) tasks and for the modular control work on the topic "Biochemical processes and transformations" - a total of 40 points (marginal evaluation 24 points). - final evaluation in the form of an exam. The maximum score is 40 points (cut-off score is 24 points). The final number of points in the discipline (maximum 100 points), which is determined as the sum of points for systematic work during the semester and the results of the exam.

Ukrainian