Infopaket

Drug development

ОК.21

Обов’язкова дисципліна для ОП

Second

2023/2024

2 Semester

4

The ability to build adequate models of chemical phenomena, to study them for obtaining new conclusions and deepening of understanding of nature, including using methods molecular, mathematical and computer modeling. Ability to organize, plan and implement a chemical experiment. The ability to interpret, objectively evaluate and present the results of one's work research. The ability to formulate new hypotheses and scientific problems in the field of chemistry, to choose directions and appropriate methods for their solution based on an understanding of modern issues research in the field of chemistry and taking into account the available resources. The ability to choose optimal research methods and techniques. Possession of the general methodology of carrying out scientific research.

The student should know: fundamentals of general, inorganic and organic chemistry, biochemistry, molecular biology, physical chemistry and supramolecular chemistry, as well as fundamentals physical research methods. The student should be able to: Use modern electronic databases in the field of chemistry and biology, other Internet resources.

The course first introduces the basic concepts and terms, general definitions, and a brief introduction historical reference. The business basics of the pharmaceutical industry, the stages, are taught search for new pharmaceuticals, basic principles of pharmacokinetics and pharmacodynamics. The concepts of clinical trials and clinical pharmacology are introduced. After that the main tools, methods and technologies for searching for biologically active substances are taught substances The course concludes with the teaching of specific methods used for FDA drug approval.

[1] Practice of Medicinal Chemistry (2nd Edition) Editor: Wermuth, C G. Elsevier, London, 2003. [2] Preclinical Development Handbook: Toxicology, edited by Shayne Cox Gad, 2008 John Wiley & Sons, Inc. [3] H. G. Vogel, J. Maas, A. Gebauer (eds.), Drug Discovery and Evaluation: Methods in Clinical Pharmacology, DOI 10.1007/978-3-540-89891-7 A.1,, Springer-Verlag Berlin Heidelberg 2011

lectures, practical

- semester assessment: 1. Modular control work 1 - RN 2. - 12 points 2. Modular control work 2 - RN 2. - 12 points 3. Modular control work 3 - RN 2. - 12 points 4. Final test - RN 1. - 12 points 5. Practical report - RN 3. - 6 points 6. Home test work. - PH 4. - 6 points - final evaluation: in the form of an exam The form of the exam is a test control robot and an interview based on it. Results training, which is evaluated in the test control work, is RN 1. The maximum number of points which can be obtained by a student, is 40 points.

Ukrainian