Infopaket

Modern concepts of organic synthesis

ОК.19

Обов’язкова дисципліна для ОП

Second

2023/2024

1 Semester

4

The ability to build adequate models of chemical phenomena, to study them for obtaining new conclusions and deepening of understanding of nature, including using methods molecular, mathematical and computer modeling. Ability to organize, plan and implement a chemical experiment. The ability to interpret, objectively evaluate and present the results of one's work research. The ability to formulate new hypotheses and scientific problems in the field of chemistry, to choose directions and appropriate methods for their solution based on an understanding of modern issues research in the field of chemistry and taking into account the available resources. The ability to choose optimal research methods and techniques. Possession of the general methodology of carrying out scientific research.

Full-time form

The student should know: fundamentals of general, inorganic and organic chemistry, biochemistry, molecular biology, physical chemistry and supramolecular chemistry, as well as fundamentals physical research methods. The student should be able to: Use modern electronic databases in the field of chemistry and biology, other Internet resources.

The course begins with the main stages of the modern drug discovery cycle. For understanding prerequisites of the current connection between organic synthesis and drug discovery, is given attention to earlier events in pharmacology, namely to the emergence of high-performance screening (HTS) in the mid-1980s. So the next part is an introduction to HTS and the role of chemistry in it, as well as the answer to the question of how it works. The next part is dedicated introducing the basic definitions of chemoinformatics, especially the concept of chemical space. After introducing the definition of chemical space, two more concepts are discussed, viz virtual navigation in chemical space and synthetic exploration of chemical space. The first concept is mostly aimed at high-quality design criteria compiled libraries. The second concerns trends and concepts observed in synthetic chemistry: syntheses focused on diversity/biology/finding leads and others. For comparison, "traditional" targeted synthesis and new methodologies are also discussed. Combinatorial chemistry approaches, which are an integral part of all, are also considered separately modern concepts related to the early stages of the development of new medicines.

1. Rydzewski, R. Real World Drug Discovery. A Chemist's Guide to Biotech and Pharmaceutical Research. Elsevier Science 2008. ISBN: 9780080466170. 2. Wermuth, C.; Aldorus, D; Raboisson, P.; Rognan, D. (Ed.) The Practice of Medicinal Chemistry. 4th Edition. Academic Press 2015. ISBN: 9780124172050. 3. Silverman, R. B.; Holladay, M. W. The Organic Chemistry of Drug Design and Drug Action. 3rd Edition. Academic Press 2014. ISBN: 9780123820303.

lectures, practical

- semester assessment: 1. Modular control work 1 - RN 2. - 12 points 2. Modular control work 2 - RN 2. - 12 points 3. Modular control work 3 - RN 2. - 12 points 4. Final test - RN 1. - 12 points 5. Practical report - RN 3. - 6 points 6. Home test work. - PH 4. - 6 points - final evaluation: in the form of an exam The form of the exam is a test control robot and an interview based on it. Results training, which is evaluated in the test control work, is RN 1. The maximum number of points which can be obtained by a student, is 40 points.

Ukrainian