Infopaket

Medical genetics

Вибіркова дисципліна для ОП

Second

2021/2022

2 Semester

5

PR4. Solve complex problems in the field of biology, generate and evaluate ideas. PR19. Solve scientific-theoretical, research and applied problems of biology by appropriate methods. PR29. Be able to use modern specialized molecular methods

External form

1. Successful mastering of the courses "Molecular Biology", "Immunology", "Virology", "General Genetics", "Biochemistry", "Human Genetics", "Oncogenetics", "Genomics", "Eukaryotic Chromosomes", "Chromatin Molecular Organization" and "Genome instability". 2. Knowledge of the theoretical foundations of chemistry, physics, molecular biology, cell biology, etc .; ability to use theoretical knowledge of these disciplines to solve practical problems. 3. Possession of basic skills in working with scientific electronic databases, scientific literature and the ability to system analysis.

The course covers the study of inheritance and variability of human pathological traits. The classification of hereditary diseases, molecular mechanisms of pathological conditions in the manifestation of chromosomal and genetic hereditary diseases are considered. WARNING. is given to hereditary predisposition to "sporadic" diseases (cancer, mental, cardiovascular diseases, etc.). The connection of different polymorphic variants of the human genome with different pathological conditions is considered. General information on pharmacokinetics and pharmacodynamics of drugs, causes of individual sensitivity to drugs, genetic variants of drug transport and metabolism systems, pharmacological aspects of genetic variants of drug target molecules are considered. Problems of appointment of individual schemes of drug therapy depending on a genotype of the patient are discussed.

1. Rushkovsky S.R. Pharmacogenetics. Lecture course. - Kyiv: NSC "Institute of Biology", 2013. 2. Jorde L.D., Carey J.C., Bamshad M.J. Medical genetics, 5th Edition. – Elsevier, 2016. 3. Skakun M.P. Pharmacogenetics. - Ternopil: Ukrmedkniga, 2002.

Lectures, laboratory work, independent work.

- semester assessment: 1. Modular test work] (remotely): PH 1.1 - 1.4 - 20 points / 10 points (block of topics of Section 1) 2. Modular test 2 (remotely): PH 1.1 - 1.4 - 20 points / 10 points (block of topics of Section 2) 3. Evaluation of laboratory work: PH 2.1 - 4.1 - 10 points / 5 points 4. Evaluation of additions, oral answers, presentations: PH 1.1 - 4.1 - 10 points / 5 points - final assessment: in the form of an exam

Ukrainian