Infopaket

Oncogenetics

Вибіркова дисципліна для ОП

First

2022/2023

9 Semester

3

PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the borders of subject areas PR05. Use knowledge and demonstrate compliance with the provisions of biological ethics, biological safety and biological protection PR08. Demonstrate knowledge of fundamental biological processes, structure and functions of living organisms PR09. Demonstrate knowledge of heredity and variability, molecular mechanisms of conservation and realization of genetic information and importance in evolutionary processes PR16. Choose methods, algorithms for planning and conducting field, laboratory, clinical and laboratory research, including mathematical methods and software for research, processing and presentation of results

External form

Successful mastering of the courses "Genetics", "Molecular Biology", "Biochemistry", "Cytology", "Human Genetics", as well as acquaintance with selected sections of human physiology, theory of evolution. Knowledge of the theoretical foundations of chemistry, physics, molecular biology, cell biology, etc .; ability to use theoretical knowledge of these disciplines to solve practical problems. Possession of basic skills in working with scientific electronic databases, scientific literature and the ability to system analysis.

The subject of the discipline "Oncogenetics" is the genetic basis of susceptibility to cancer, molecular genetic mechanisms of initiation and progression of tumors. General ideas about oncological diseases, causes and mechanisms of cell transformation as a result of chemical, physical and biological carcinogens, the role of genotype in cancer are considered. Attention is paid to molecular genetic processes that are disrupted at different stages of cell malignancy, genetic control of angiogenesis and metastasis. The issues of cancer prevention and determination of individual risk of tumor formation are discussed.

1. Rushkovsky S.R. Oncogenetics. Lecture course. - Kyiv: NSC "Institute of Biology", 2013. 2. Bunz F. Principles of cancer genetics. – Springer Verlag, 2016. 3. Molecular and Cell Biology of Cancer// ed. by Fior R., Zilhão R. – Springer Verlag, 2019. 4. Bozzone D. Cancer genetics. – N-Y.: Infobase Publishing, Inc., 2007 5. Speicher M.R., Antonarakis S.E., Motulsky A.G. Vogel and Motulsky's Human Genetics. Problems and applications. – Berlin: Springer, 2010. 6. Sherbet G.V. Lakshmi M.S. Genetics of Cancer: Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation. – Elsevier Ltd., 2007. 7. Pitot H.C. fundamentals of oncology. – N-Y.: Marcel Dekker, Inc., 2002.

Lectures, independent work

Semester assessment: 1. Modular test 1: PH 1.1, 1,2, 2.1 - 2 .5 (remotely) - 20 points / 10 points 2. Modular test work 2: PH 1.3 - 2.5 - 20 points / 10 points 3. Solving practical problems: PH 2.1 - 3.1 - 10 points / 5 points 4. Evaluation of additions, answers, abstract: PH 1.1 - 3.1 - 10 points / 5 points Final assessment: in the form of an exam

Ukrainian