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Modern physicochemical methods in genetics

Вибіркова дисципліна для ОП

First

2022/2023

8 Semester

3

PR04. Understand the basic terms, concepts, principles, theories and laws in the field of biological sciences and on the boundaries of subject areas. PR07. Demonstrate knowledge of the structural organization of biological systems at the molecular level of the organization. PR15. Apply in professional activities methods for determining the structural and functional characteristics of biological systems at different levels of the organization. PR16. Choose methods, algorithms for planning and conducting field, laboratory, clinical and laboratory research, including mathematical methods and software for research, processing and presentation of results. PR17. Through self-study to master new knowledge and modern methods of experimental research to solve problems of biology. PR19. Solve applied problems of biology by appropriate methods.

External form

Successful mastering of the courses "Genetics", "Molecular Biology", "Biochemistry", "Biophysics". Knowledge of theoretical foundations of chemistry, physics, genetics, biochemistry and biophysics. Possession of basic skills in working with laboratory equipment, the ability to perform laboratory and practical work, work with scientific literature. Ability to work in Excel and Origin, skills in working with electronic databases.

The course is devoted to the study of the principles of modern physicochemical research methods and features of their application in the analysis of biological macromolecules and interactions between them. Possibilities and limitations of the basic physical and chemical methods, principles of a choice of a method concerning the purpose of research are shown. Covers methods that can be used in conducting research in related sciences and in interdisciplinary projects, and which require in-depth knowledge of the discipline. Particular attention is paid to modern physico-chemical methods used in the diagnosis and prognosis of genetic diseases in medical practice in Ukraine and around the world.

1. Afanas'eva K.S. Physical methods in molecular genetics. Workshop. К.: Publishing and printing center "Kyiv University", 2016, 127 p. 2. Ostapchenko L.I., Rybalchenko V.K. Biological and bioorganic chemistry. In 2 volumes - K .: Publishing and Printing Center "Kyiv University", 2014, 1043 p. 3. Sivolob A.V. Molecular biology. - K .: Publishing and printing center "Kyiv University", 2008, 384 p. 4. Serdyuk IR, Zaccai N.R., Zaccai J. Methods in molecular biophysics – Cambridge: Cambridge University Press, 2007, 1120 p. 5. Rautenstrauss B.W., Liehr T. FISH technology. – Berlin: Springer, 2012, 494 p.

Lectures, independent work

Semester assessment: 1. Modular tests 1 and 2 (the first is carried out remotely): RN 1.1 - 2.3– 40 points / 20 points 2. Solution of research problems: RN 2.1 - 3.1 - 10 points / 5 points 3. Evaluation of oral and written answers: RN 1.1 - 3.1 - 10 points / 5 points Final assessment: in the form of an exam

Ukrainian