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Physics of living systems and biophysics

ОК.09

Обов’язкова дисципліна для ОП

Second

2022/2023

1 Semester

3

The student should know: The current state and prospects for the development of biophysics. Basics of protein biophysics. Structure and physical properties of cell membranes. The Nernst-Planck equation for the flow of substances through a membrane. The Thomas equation for the transmembrane potential with active transport in mind. The Nernst equation. Goldman-Hodgkin-Katz equation for equilibrium transmembrane potentials. Cable equation of nerve impulse propagation along axons. The speed of nerve impulse propagation. Features of myelinated fiber. Synaptic transmission of excitation. Principles of information coding in sensor systems. The student should be able to: Apply experimental methods of protein research, and in particular, optical methods in the biophysics of macromolecules. To introduce experimental methods of registration and measurement of ion currents of the plasma membrane and individual ion channels. Solve problems related to the thermodynamics of living systems.

Full-time form

The course is a continuation of the cycle of applied physics courses. Knowledge of the classical sections of general physics, higher mathematics (mathematical analysis, differential equations), the basics of biophysics and organic chemistry is necessary for successful mastering of the course.

Providing students with physical knowledge, formation of scientific views, abilities, basic skills in the field of science of physical mechanisms and physico-chemical processes that underlie the vital activity of biological objects and systems at various levels of their organization - molecular, membrane, cellular, organic.

1. Біофізика: підручник / П. Г. Костюк, В. Л. Зима, І. С. Магура та ін.; за ред. П. Г. Костюка. - Київ: Обереги, 2001. - 544 с. 2. Реєстрація, обробка та контроль біомедичних сигналів: навч. посіб. / В. Г. Абакумов, З. Ю. Готра, С. М. Злепко та ін. - Вінниця: ВНТУ, 2011. - 352 с. 3. Фізика біосистем у формулах, термінах, схемах: навч. посіб. / Т. Л. Давидовська, О. В. Цимбалюк, І. С. Войтешенко та ін.; за ред Д. М. Говоруна, Н. Є. Нурищенко. - Київ: КОМПРИНТ, 2017. - 226 с. 4. Федишин Я. І. Фізика з основами біофізики: навч. посіб / Я. І. Федишин - Лвів: Світ, 2000. - 458 с. 5. Jackson M. B. Molecular and cellular biophysics / M. B. Jackson. -Cambridge: Cambridge University Press, 2006. - 528 pp.

Lectures - 16 hours, practical training - 14 hours.

Semester assessment: the academic discipline has two meaningful modules, each of which is assessed within 25 points (total 50 points). Final assessment - credit. Assessment form: written-oral (еxamination ticket for 2 questions and a test for 30 questions - total 50 points

Ukrainian