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Modern chemistry of drugs

ВКП.7.04

Вибіркова дисципліна для ОП

First

2022/2023

1 Semester

4

Р01. Knowledge to understand key chemical concepts, essential facts, concepts, principles, and theories relating to natural sciences... Р03. Skill to describe chemical data in symbolic form. Р05. Knowledge to understand the relationship between structure and properties of substances. Р11. Skill to describe properties of aliphatic, aromatic, heterocyclic, and organometallic compounds, to explain nature and behavior of functional groups in organic molecules. Р12. To know main synthesis pathways in organic chemistry, including f interconversion of functional group and formation of carbon-carbon, carbon-heteroatom bonds. Р13. Skill to analyze and evaluate data, to synthesize new ideas concerning chemistry and its applications.

Full-time form

1. Know the basic concepts of organic chemistry. 2. Be able to draw formulas of organic compounds. 3. Have basic skills in writing organic reactions. 4. Have basic knowledge of general chemistry. 5. Have an understanding of the basics of organic chemistry.

Modern approaches to the creation of medicines. Basic concepts of medical chemistry, basic biological targets of drugs (enzymes, receptors, ion channels, transport proteins and nucleic acids, protein-protein interactions), general modern scheme of drug development, strategies and methods for identifying leader compounds, modern drug search technologies (high-performance screening and fragment-oriented drug search and virtual screening), criteria for selecting compounds for drug development.

1. Kovtunenko V. O. Medicines with an effect on the central nervous system. - Kyiv, Perun, 1997. - 462 p. 2. Kovtunenko V. O. Medicines with an effect on the peripheral nervous system. - Kyiv, 2005. - 426 p. 3. Volovenko Yu. M., Kovtunenko V. O. Polymer level of organization of matter. - Kyiv, 2013. - 335 p. 4. Grygorenko O. O., Volochnyuk D. M., Ryabukhin S. V., Judd D. B. The symbiotic relationship between drug discovery and organic chemistry. – Chem. Eur. J., 2019, DOI: 10.1002/chem.201903232.

Сombination of lectures and practical exercises

Semester control includes work in practical classes, including oral examinations, tests and surveys on the topics of tests. Evaluation is carried out on a 100-point system. The maximum / minimum number of points that can be obtained by a student during the semester assessment is 100 points / 60 points.

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